Diet-Induced Thermogenesis: A Comparison of Whole and Processed Foods
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 主要终点
- Changes in resting energy expenditure will be assessed via indirect calorimetry
研究概览
简要总结
This study will examine differences in diet-induced thermogenesis (DIT) between a meal made of processed ingredients and an equivalent, isocaloric meal made of whole ingredients. For the purpose of this study processed foods (PFs) will be considered those that are purchased in a state that is modified from their whole food (WF) counterpart (e.g. shell eggs compared to powdered eggs). Research has shown that less energy is expended to digest processed foods than whole foods, which confers an advantage to processed foods in terms of caloric efficiency, but a disadvantage in terms of energy balance and weight loss. A 2010 study showed that subjects expended approximately 10% less energy to digest sandwiches made of white bread and cheese product compared to sandwiches made of whole grain bread and cheddar cheese. The intent of this study is to enhance those results and improve upon the study design by constructing meals to be more similar in the makeup of individual ingredients, making ingredient processing a more isolated variable. Subjects will be healthy CWU male students with a body mass index of 18.5 - 24.9 kg/m2. Metabolism will be assessed by repeated measurements of resting energy expenditure via indirect calorimetry. Measurements of baseline metabolism will be made; subjects will then be provided one of two meals, both comprised of rice, green beans, and eggs cooked in canola oil and equivalent but differing in processing status (e.g. brown rice and white rice, fresh cooked green beans and canned green beans, etc). Hourly metabolic measurements will be made post-meal for 6 hours. During this time subjects will be asked to minimize non-DIT deviations in metabolism; e.g. those due to physical activity, excitement level, etc. The procedure will be repeated one week later with the other meal so that changes in DIT can be assessed on a subject-by-subject basis. The results of this study will be assessed in the lens of weight loss, specifically dietary choices that affect energy balance. It is possible that consuming a diet that includes more whole foods (versus processed foods) would be beneficial to the attainment of a healthy body weight - either through potential weight loss or weight maintenance.
详细描述
This study will be a crossover design that will use indirect calorimetry to assess changes in metabolic rates in twelve healthy subjects prescreened for any known metabolic abnormalities. Subjects will be recruited from healthy CWU male students of a normal BMI range that express interest in research study participation. Subjects will be assigned either a meal made of whole ingredients (whole grain brown rice, unrefined canola oil, scrambled eggs from the shell, freshly-steamed green beans) or one made of processed ingredients (white rice, canola oil-based margarine, scrambled eggs from a powdered mix, canned green beans). Subjects will have a basal metabolic rate (BMR) measurement taken before ingesting the meal and DIT will be measured on an hourly basis post meal.
PROCEDURE:
Early Meal Preparation:
Meal preparation will begin the night prior to each testing session by cooking 2 cups of dry rice per the package instructions and chilling it in a shallow stainless steel pan. This rice will be refrigerated overnight and re-heated portion-by-portion for the following morning's meal feeding. Three portions of one cup's worth of fresh green beans will also be washed, trimmed, cut into one-inch pieces, and refrigerated.
Initial Testing:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 25 Years(Adult)
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Ages 18 - 25 years
- •BMI: 18.5 - 29.9 kg/m2
排除标准
- •Diagnosed with cardiovascular disease, cancer, diabetes, thyroid disorder, metabolic disorders, eating disorders, and/or egg allergy
结局指标
主要结局
Changes in resting energy expenditure will be assessed via indirect calorimetry
时间窗: Resting energy expenditure will be assessed at baseline and post-baseline at hours 1, 2, 3, 4, 5, & 6 for a total of 7 measurements
次要结局
未报告次要终点
研究者
Nicole Stendell-Hollis
Assistant Professor
Central Washington University
