Trimester Sequential Estimation of Serum Zonulin as a Predictor of Gestational Diabetes Mellitus
- Conditions
- Gestational Diabetes
- Interventions
- Diagnostic Test: ELISA
- Registration Number
- NCT06336512
- Lead Sponsor
- Benha University
- Brief Summary
Gestational diabetes mellitus (GDM) is the development of glucose intolerance (GI) during pregnancy in a previously normoglycemic (NG) woman and associated with insulin resistance (IR). GDM is the most prevalent metabolic disorder during pregnancy and became a major public health problem for being usually diagnosed and detected after 24 gestational weeks (GW), while its complications can occur much earlier and this may explain its burden on maternal and fetal welfare. Human zonulin is a surrogate marker of intestinal permeability and can be utilized as biomarker for intestinal barrier function. Zonulin-mediated increase in intestinal permeability plays a role in the pathogenesis of insulin resistance, obesity, DM and metabolic syndrome. The increasing global prevalence of GDM with its associated risk of poor pregnancy and long-term risks for the mother and the offspring may lead to the production of new generation of diabetics.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 70
- Pregnant Women with singleton fetus
- Women with morbid obesity with body mass index ≥35 kg/m2;
- Had manifest DM, irrespective of being controlled or not;
- Bowel-related disorders;
- Autoimmune disorders;
- History of previous GDM.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description serum zonulin ELISA -
- Primary Outcome Measures
Name Time Method Estimation of Gestational DM 8 months Relation between Serum Zonulin levels and Gestational Diabetes Mellitus
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Benha university
🇪🇬Banhā, El- Qalyobia, Egypt