A Retrospective Study of the Effect of Different Drugs Co-administration in the Treatment of Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 702
- 主要终点
- The B-type natriuretic peptide (BNP)
研究概览
简要总结
The goal of this observational study is to assess the effect of the different combination of drugs in the treatment of heart failure.
The main questions it aims to answer are:
- [question 1] The changes of BNP and LVEF in patients of each groups with different drugs co-administration.
- [question 2] The days of hospitalization, degree of lower limb edema (mild, moderate, severe) and 6-minute walking test in each groups.
Participants will be asked to do nothing. All the records of the patients will be download from the Big Data Cloud Platform of Health Care in the First Affiliated Hospital of Shandong First Medical University.
There is not a comparison group.
详细描述
The purpose of this study is to evaluate the efficacy and cost-effective of different drugs co-administration in the treatment of heart failure. For different reasons, patients with heart failure took different drug prescriptions. Now there are five kinds of drugs for the treatment of heart failure, such as angiotensin converting enzyme inhibitor or angiotensin receptor blocker (ACEI/ARB), beta-blokers, spironolactone, sodium-glucose cotransporter (sglt) 2 inhibitors and vericiguat. Our purpose is to assessment the efficacy and cost-effective of different drugs co-administration in the treatment of heart failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed as "heart failure" or "cardiac insufficiency" on the first page of the medical record
排除标准
- •Severe impairment of liver, kidney and lung function (transaminase increased more than 2 times; Scr > 265umol/L); malignant tumor
结局指标
主要结局
The B-type natriuretic peptide (BNP)
时间窗: Admission to hospital and 12 months thereafter
B-type natriuretic peptide (BNP) is a marker of heart failure. Its levels can be measured with a rapid and commercially available bed-side assay. Rising levels correlate with the degree of left ventricular dysfunction and severity of symptoms.
Left ventricular ejection fraction (LVEF) of patients
时间窗: Admission to hospital and 12 months thereafter
Echocardiography is the gold standard for establishing the presence of left ventricular dysfunction. Left ventricular ejection fraction (LVEF) is the central measure of left ventricular systolic function. LVEF is the fraction of chamber volume ejected in systole (stroke volume) in relation to the volume of the blood in the ventricle at the end of diastole (end-diastolic volume).
Hospital mortality
时间窗: Index hospital stay
We recorded the death from heart failure, no matter the mode of death.
次要结局
- Days of hospitalization and expenses of patients(Index hospital stay)
- 6-minute walking test(Admission to hospital and 12 months thereafter)
- degree of lower limb edema (mild, moderate, severe)(Admission to hospital and 12 months thereafter)
研究者
Guang Yang
Director of Department of Gerontology/ Health Care and Medicine (Cardiology) , the First Affiliated Hospital of Shandong First Medical University &Shandong Provincial Qianfoshan Hospital
Qianfoshan Hospital