Testing the Efficacy and Safety of Niacinamide Cosmetic Preparation: A Randomised, Controlled Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- skin oiliness assessment with sebumeter probe
Study Overview
Brief Summary
Niacinamide in lower concentrations has been recognized as a cosmetic ingredient with hydrating properties. Therefore, aim was to test the efficacy and safety of niacinamide cosmetic preparation in A Randomized, Controlled Trial.
Detailed Description
Skin hydration (as use of hydrating cosmetic ingredients) is one of the most interventions for healthy skin and skin barrier function. Therefore, cosmetic ingredients used for this purpose should be examined for their efficacy.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy volunteers who gave written informed consent
Exclusion Criteria
- •skin disease, skin damage on measurement sites, use of corticosteroids and immunomodulators a month prior to the inclusion and during the trial, non-adherence to the trial protocol, exposure to artificial UV radiation, pregnancy and lactation
Outcomes
Primary Outcomes
skin oiliness assessment with sebumeter probe
Time Frame: through study completion, an average of 1 year
sebum level
Hydration assessment with corneometer probe
Time Frame: through study completion, an average of 1 year
stratum corneum hydration
TEWL assessment with Courage Khazaka probe
Time Frame: through study completion, an average of 1 year
Transepidermal water loss
pigmentation assessment with mexameter probe
Time Frame: through study completion, an average of 1 year
erythema and melanin
Secondary Outcomes
- subjective opinion of participants(through study completion, an average of 1 year)
Investigators
Dario Leskur
assistant professor
University of Split, School of Medicine