Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Out of Hospital Cardiac Arrest
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- AfterROSC
- 入组人数
- 907
- 试验地点
- 27
- 主要终点
- Determination of Area Under Curve of Cerebral Admission Hospital Prognosis (CAHP) Score at intensive care unit admission
研究概览
简要总结
Even in patients with successful return of spontaneous circulation (ROSC), outcome after cardiac arrest remains poor. The overall in-hospital survival rate widely varies both worldwide and across communities, from 1 to 4 folds according to circumstances of arrest and post-resuscitation interventions. Several studies have already shown that early interventions performed after ROSC, such as treatment of the cause, targeted temperature management, optimal hemodynamic management and extra-corporeal life support in selected patients, could improve the outcome in post-cardiac arrest patients. However, the decision process regarding the allocation of these resources, in parallel with the management of patients' proxies, remains a complex challenge for physicians facing these situations. Consequently, several prediction models and scores have been developed in order to stratify the risk of unfavorable outcome and to discriminate the best candidates for post-resuscitation interventions. Overall, several scores exist, but external validation are lacking and direct comparisons are needed to assess relative interest of scoring systems. Indeed, establishing the optimal scoring system is crucial, for optimal treatment allocation and appropriate information to relatives.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All adult patients, major, admitted to intensive care after out-of-hospital cardiac arrest and comatose (defined by Glasgow score ≤ 8) on admission.
排除标准
- •cardiac arrest occurring intra-hospital,
- •minor patient,
- •major patient under guardianship,
- •protected persons,
- •prior inclusion in the study
结局指标
主要结局
Determination of Area Under Curve of Cerebral Admission Hospital Prognosis (CAHP) Score at intensive care unit admission
时间窗: Intensive Care Unit Admission (Usually 3 hours after cardiac arrest)
Determination of AUC for CAHP score as compare to Utstein style criteria. CAHP score range from 0 to 300 with higher score indicates poorer prognosis
次要结局
- Determination of Area Under Curve of OHCA Score at intensive care unit admission(Intensive Care Unit Admission (Usually 3 hours after cardiac arrest))
- Determination of calibration of each score(Intensive Care Unit Admission (Usually 3 hours after cardiac arrest))
- Determination of Area Under Curve of modified CAHP Score at intensive care unit admission(Intensive Care Unit Admission (Usually 3 hours after cardiac arrest))
- Determination of Area Under Curve of NULL-PLEASE Score at intensive care unit admission(Intensive Care Unit Admission (Usually 3 hours after cardiac arrest))
- Determination of Area Under Curve of CREST Score at intensive care unit admission(Intensive Care Unit Admission (Usually 3 hours after cardiac arrest))
- Determination of Area Under Curve of C-Graph Score at intensive care unit admission(Intensive Care Unit Admission)
- Determination of Area Under Curve of simplified CAHP Score at intensive care unit admission(Intensive Care Unit Admission (Usually 3 hours after cardiac arrest))
- Determination of Area Under Curve of TTM Score at intensive care unit admission(Intensive Care Unit Admission (Usually 3 hours after cardiac arrest))