A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)
- Conditions
- Chronic Heart Failure With Reduced Ejection Fraction
- Interventions
- Drug: Placebo
- Registration Number
- NCT05093933
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Brief Summary
The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had a recent hospitalization for heart failure or need for outpatient intravenous (IV) diuretics. The primary hypothesis is that vericiguat is superior to placebo in reducing the risk of cardiovascular death or heart failure hospitalization.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6105
- History of chronic HF [New York Heart Association (NYHA) Class II to IV] on guideline-directed medical therapy for heart failure (GDMT) with no HF hospitalization within 6 months or outpatient IV diuretic use within 3 months before randomization.
- Left ventricular ejection fraction (LVEF) of ≤40%, assessed within 12 months before randomization by any imaging method.
- Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels.
- A female participant is eligible to participate if she is not pregnant or breastfeeding, is not a woman of childbearing potential (WOCBP), or is a WOCBP and agrees to follow contraceptive guidance during the study intervention period and for at least 1 month after the last dose of study intervention.
- Has SBP <100 mm Hg or symptomatic hypotension.
- Awaiting heart transplantation, is receiving continuous IV infusion of an inotrope, or has or anticipates receiving an implanted ventricular assist device.
- Amyloidosis or sarcoidosis.
- Primary valvular heart disease requiring surgical procedure or intervention or has undergone a valvular surgical procedure or intervention within 3 months before randomization.
- Hypertrophic cardiomyopathy.
- Acute myocarditis or Takotsubo cardiomyopathy.
- History of heart transplant.
- Tachycardia-induced cardiomyopathy and/or uncontrolled tachyarrhythmia.
- Acute coronary syndrome, or undergone coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) within 3 months before randomization.
- History of symptomatic carotid stenosis, transient ischemic attack (TIA), or stroke within 3 months before randomization.
- Malignancy or other noncardiac condition limiting life expectancy to <3 years.
- Requires continuous home oxygen for severe pulmonary disease.
- Interstitial lung disease.
- Discontinuation or dose modification of GDMT or vericiguat within 4 weeks before randomization.
- Recent history (within the last year) of drug or alcohol abuse or dependence.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Vericiguat Vericiguat Participants receive a starting dose of 2.5 mg of vericiguat taken orally once daily. The vericiguat dose will be titrated to 5 mg and to 10 mg. Placebo Placebo Participants receive a starting matching placebo to vericiguat dose of 2.5 mg taken orally once daily. The matching placebo dose will be sham titrated to 5 mg and to 10 mg.
- Primary Outcome Measures
Name Time Method Time to First Occurrence of Composite Endpoint of Cardiovascular (CV) Death or Heart Failure (HF) Hospitalization From date of randomization until the date of first occurrence of a CV death or HF hospitalization, assessed up to approximately 40 months The first event of CV death or HF hospitalization as confirmed by a clinical events committee (CEC).
- Secondary Outcome Measures
Name Time Method Time to Total HF Hospitalizations (Including First and Recurrent Events) Up to approximately 40 months All events of HF hospitalization as confirmed by a CEC.
Time to First Occurrence of Composite Endpoint of All-Cause Mortality or HF Hospitalization From date of randomization until the date of first occurrence of death or HF hospitalization, assessed up to approximately 40 months The first event of death due to any cause or HF hospitalization as confirmed by a CEC.
Time to First Occurrence of HF Hospitalization From date of randomization until the date of first occurrence of a HF hospitalization, assessed up to approximately 40 months The first event of HF hospitalization as confirmed by a CEC.
Time to First Occurrence of CV Death From date of randomization until the date of first occurrence of a CV death, assessed up to approximately 40 months The first event of CV death as confirmed by a CEC.
Time to All-Cause Mortality From date of randomization until the date of death, assessed up to approximately 40 months The first event of death due to any cause as confirmed by a CEC.
Percentage of Participants who Experienced One or More Selected Nonserious Adverse Events (NSAEs) Up to approximately 40 months An adverse event (AE) is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention. Selected NSAEs are nonserious AEs that meet any of the following criteria: AEs that lead to study intervention dose modification or discontinuation, AEs that lead to withdrawal from the study, or coronavirus disease (COVID-19) disease-related AEs.
Percentage of Participants Who Experienced One or More Events of Clinical Interest (ECIs) Up to approximately 40 months Events of clinical interest will include: 1) Potential drug-induced liver injury (DILI) events defined as: elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) laboratory value that is greater than or equal to 3X the upper limit of normal (ULN) and an elevated total bilirubin laboratory value that is greater than or equal to 2X the ULN and, at the same time, an alkaline phosphatase laboratory value that is less than 2X the ULN, as determined by way of protocol specified laboratory testing or unscheduled laboratory testing, 2) Symptomatic hypotension 3) Anemia.
Percentage of Participants Who Experienced One or More Serious Adverse Events (SAEs) Up to approximately 40 months An SAE is defined as any untoward medical occurrence that, at any dose: Results in death, is life threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital anomaly/birth defect, or is another important medical event, as judged medically or scientifically, that may not be immediately life-threatening or result in death or hospitalization but may jeopardize the participant or may require medical or surgical intervention to prevent one of the other outcomes listed above.
Trial Locations
- Locations (519)
G A Research Associates ( Site 0652)
🇨🇦Moncton, New Brunswick, Canada
South Florida Research Solutions ( Site 0058)
🇺🇸Hollywood, Florida, United States
Georgia Arrhythmia Consultants and Research Institute ( Site 0042)
🇺🇸Macon, Georgia, United States
Logan Health Research ( Site 0017)
🇺🇸Kalispell, Montana, United States
The Valley Hospital ( Site 0035)
🇺🇸Ridgewood, New Jersey, United States
Pulse Heart Institute - Puyallup ( Site 0119)
🇺🇸Puyallup, Washington, United States
Royal Adelaide Hospital-Cardiology ( Site 0456)
🇦🇺Adelaide, South Australia, Australia
King's College Hospital-Cardiac Research Department ( Site 4154)
🇬🇧London, England, United Kingdom
ClinPhenomics CVC GmbH ( Site 1457)
🇩🇪Frankfurt, Hessen, Germany
Istanbul University Cerrahpasa Medical School Internal Diseases Institute-CARDIOLOGY INSTITUTE ( Sit
🇹🇷Istanbul, Turkey
West Houston Area Clinical Trial Consultants ( Site 0014)
🇺🇸Houston, Texas, United States
Cardiovascular Research Center of South Florida ( Site 0074)
🇺🇸Miami, Florida, United States
Cumberland Infirmary ( Site 4174)
🇬🇧Carlisle, Cumbria, United Kingdom
The First Hospital of Harbin Medical University-Cardiology ( Site 0903)
🇨🇳Harbin, Heilongjiang, China
Wuxi No.2 People's Hospital-Cardiology Department ( Site 0877)
🇨🇳Wuxi, Jiangsu, China
The Second Affiliated Hospital of Nanchang University-Cardiology ( Site 0912)
🇨🇳Nanchang, Jiangxi, China
Siping Central People's Hospital-Cardiovascular Department ( Site 0915)
🇨🇳Siping, Jilin, China
The First Affiliated Hospital of Xian Jiaotong University ward1 depattment of medical oncology ( Sit
🇨🇳Xi'an, Shaanxi, China
Shanghai Yangpu District Central Hospital-Cardiology ( Site 0876)
🇨🇳Shanghai, Shanghai, China
West China Hospital Sichuan University ( Site 0904)
🇨🇳Cheng Du, Sichuan, China
The Second Hospital of Tianjin Medical University-Endocrinology ( Site 0902)
🇨🇳Tianjin, Tianjin, China
Tianjin People' s Hospital ( Site 0867)
🇨🇳Tianjin, Tianjin, China
Shanghai Xuhui Central Hospital-Cardiovascular Department ( Site 0872)
🇨🇳Shanghai, Shanghai, China
The First Affiliated Hospital, Zhejiang University ( Site 0907)
🇨🇳Hangzhou, Zhejiang, China
The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0909)
🇨🇳Hangzhou, Zhejiang, China
Zhejiang Provincial People's Hospital ( Site 0914)
🇨🇳Hangzhou, Zhejiang, China
People's Hospital of Lishui City-department of cardiovascular ( Site 0862)
🇨🇳Lishui, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University-Vasculocardiology Department ( Site 0874
🇨🇳Wenzhou, Zhejiang, China
The Adam Practice ( Site 4180)
🇬🇧Poole, United Kingdom
Vanderbilt University Medical Center-Vanderbilt Heart and Vascular Institue ( Site 0060)
🇺🇸Nashville, Tennessee, United States
South Texas Cardiovascular Consultants, PLLC-Research ( Site 0020)
🇺🇸San Antonio, Texas, United States
St. Boniface General Hospital ( Site 0667)
🇨🇦Winnipeg, Manitoba, Canada
Enhancing Care Foundation ( Site 3456)
🇿🇦Durban, Kwazulu-Natal, South Africa
Ege University Medicine of Faculty-Cardilogy Department ( Site 4054)
🇹🇷Bornova, Izmir, Turkey
Communal Enterprise "Hospital #1" of Zhytomyr City Council-Advisory and Treatment department of Sci
🇺🇦Zhytomyr, Zhytomyrska Oblast, Ukraine
Hospital Mae de Deus ( Site 0564)
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Peace River Cardiovascular Center ( Site 0088)
🇺🇸Port Charlotte, Florida, United States
Centro de Investigaciones Metabólicas (CINME)-Cardiology ( Site 4352)
🇦🇷Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Krankenhaus St. Josef Braunau ( Site 0354)
🇦🇹Braunau, Oberosterreich, Austria
Cardiovascular Institute of the South ( Site 0072)
🇺🇸Houma, Louisiana, United States
Phillips Medical Services ( Site 0070)
🇺🇸Jackson, Mississippi, United States
BAYCARE MEDICAL GROUP ( Site 0099)
🇺🇸Safety Harbor, Florida, United States
Cardiovascular Institute of the South ( Site 0081)
🇺🇸Opelousas, Louisiana, United States
Holy Cross Hospital ( Site 0100)
🇺🇸Fort Lauderdale, Florida, United States
The University of Mississippi Medical Center-Cardiovascular ( Site 0073)
🇺🇸Jackson, Mississippi, United States
ProLive Medical Research ( Site 0032)
🇺🇸Miami, Florida, United States
University of Florida - Jacksonville ( Site 0169)
🇺🇸Jacksonville, Florida, United States
Cardiovascular Center of Sarasota ( Site 0154)
🇺🇸Sarasota, Florida, United States
Ascension Providence Hospital ( Site 0094)
🇺🇸Southfield, Michigan, United States
The Heart Clinic - Hammond ( Site 0155)
🇺🇸Hammond, Louisiana, United States
IMA Clinical Research ( Site 0112)
🇺🇸Monroe, Louisiana, United States
Maryland Cardiovascular Specialists ( Site 0056)
🇺🇸Baltimore, Maryland, United States
Cardiovascular Institute of the South, 3 ( Site 0096)
🇺🇸Lafayette, Louisiana, United States
CEDIC ( Site 4363)
🇦🇷Caba, Buenos Aires, Argentina
DIM Clínica Privada ( Site 4359)
🇦🇷Ramos Mejía, Buenos Aires, Argentina
Cardiovascular Associates of the Delaware Valley ( Site 0097)
🇺🇸Washington Township, New Jersey, United States
Instituto de Investigaciones Clinicas Zarate ( Site 4360)
🇦🇷Zárate, Buenos Aires, Argentina
Medizinische Universität Graz-Department of Cardiology ( Site 0351)
🇦🇹Graz, Steiermark, Austria
Renown Regional Medical Center-Renown Institute for Heart and Vascular Health ( Site 0168)
🇺🇸Reno, Nevada, United States
Amici Clinical Research LLC-Research ( Site 0037)
🇺🇸Raritan, New Jersey, United States
Fundacion Estudios Clinicos ( Site 4356)
🇦🇷Rosario, Santa Fe, Argentina
Victoria Heart Institute Foundation ( Site 0680)
🇨🇦Victoria, British Columbia, Canada
Centro de Investigaciones Clinicas del Litoral ( Site 4354)
🇦🇷Santa Fe, Argentina
Imed19-privat ( Site 0353)
🇦🇹Vienna, Wien, Austria
Uniklinikum Salzburg-Universitätsklinik für Innere Medizin II, Kardiologie, Internistische Intensiv
🇦🇹Salzburg, Austria
Hospital Pro-Cardiaco ( Site 0556)
🇧🇷Rio de Janeiro, Brazil
Unité de Recherche Clinique du CISSS des Laurentides ( Site 0668)
🇨🇦St-Jerome, Quebec, Canada
Espacio Eme ( Site 0762)
🇨🇱Santiago, Region M. De Santiago, Chile
Clínica Ensenada ( Site 0753)
🇨🇱Santiago, Region M. De Santiago, Chile
Cardio Sur ( Site 0756)
🇨🇱Santiago, Region M. De Santiago, Chile
Apex Research Foundation ( Site 0001)
🇺🇸Jackson, Tennessee, United States
Flinders Medical Centre-Cardiology Research ( Site 0455)
🇦🇺Bedford Park, South Australia, Australia
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer
🇨🇦Sherbrooke, Quebec, Canada
Heritage Medical Research Clinic ( Site 0679)
🇨🇦Calgary, Alberta, Canada
PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR ( Site 0555)
🇧🇷Curitiba, Parana, Brazil
Klinikum Coburg ( Site 1464)
🇩🇪Coburg, Bayern, Germany
St. Vinzenz-Hospital-Cardiology ( Site 1455)
🇩🇪Cologne, Nordrhein-Westfalen, Germany
Gemeinschaftspraxis Dr. Fabian Krämer, Dr. Ulrich Overhoff ( Site 1459)
🇩🇪Siegen, Nordrhein-Westfalen, Germany
Royal Brisbane and Women's Hospital-Cardiology Research ( Site 0453)
🇦🇺Brisbane, Queensland, Australia
Rodrigo Botero S.A.S ( Site 0953)
🇨🇴Medellín, Antioquia, Colombia
Fundacion Valle del Lili- CIC-Internal Medicine ( Site 0962)
🇨🇴Cali, Valle Del Cauca, Colombia
Diex Recherche Trois-Rivieres ( Site 0677)
🇨🇦Trois-Rivieres, Quebec, Canada
CHU Bordeaux Haut-Leveque ( Site 1362)
🇫🇷Pessac, Aquitaine, France
Hospital de Clínicas de Ribeirão Preto ( Site 0559)
🇧🇷Ribeirão Preto, Sao Paulo, Brazil
Montreal General Hospital ( Site 0653)
🇨🇦Montreal, Quebec, Canada
Enroll SpA ( Site 0755)
🇨🇱Santiago, Region M. De Santiago, Chile
Clinica Dermacross ( Site 0760)
🇨🇱Santiago, Region M. De Santiago, Chile
Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 1356)
🇫🇷Le Kremlin-Bicêtre, Paris, France
Asklepios Klinik Langen ( Site 1473)
🇩🇪Langen, Hessen, Germany
Staedtisches Klinikum Dresden-2. Medizinische Klinik ( Site 1468)
🇩🇪Dresden, Sachsen, Germany
General Hospital of Athens "G. Gennimatas"-General Hospital of Athens "G.Gennimatas" ( Site 1561)
🇬🇷Athens, Attiki, Greece
CHU Rangueil-Cardiology ( Site 1351)
🇫🇷Toulouse, Haute-Garonne, France
Institut de Cardiologie de Montreal ( Site 0661)
🇨🇦Montreal, Quebec, Canada
Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0754)
🇨🇱Santiago, Region M. De Santiago, Chile
Clinica de la Costa S.A.S. ( Site 0954)
🇨🇴Barranquilla, Atlantico, Colombia
IPS Centro Científico Asistencial S.A.S ( Site 0952)
🇨🇴Barranquilla, Atlantico, Colombia
Katholisches Krankenhaus St. Johann Nepomuk ( Site 1462)
🇩🇪Erfurt, Thuringen, Germany
Grantham Hospital ( Site 1753)
🇭🇰Aberdeen, Hong Kong
Kaplan Medical Center-Heart Institution ( Site 2054)
🇮🇱Rehovot, Israel
ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 2159)
🇮🇹Milan, Milano, Italy
Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 2157)
🇮🇹Pavia, Italy
Hospital Universiti Sains Malaysia-Medical Department ( Site 2357)
🇲🇾Kubang Kerian, Kelantan, Malaysia
Sarawak Heart Centre ( Site 2352)
🇲🇾Kota Samarahan, Sarawak, Malaysia
HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA ( Site 2478)
🇲🇽México, Distrito Federal, Mexico
Hospital Alberto Sabogal Sologuren ( Site 2851)
🇵🇪Bellavista, Qallaw, Peru
Clínica Vesalio-Cardiology ( Site 2854)
🇵🇪Lima, Peru
Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu-Oddz.Klin.Kardiologii i Int.T.Kard. ( Si
🇵🇱Toruń, Kujawsko-pomorskie, Poland
Cardiologicum Hamburg ( Site 1467)
🇩🇪Hamburg, Germany
Óbudai Egészségügyi Centrum ( Site 1861)
🇭🇺Budapest, Hungary
Clinical Research Chile SpA ( Site 0761)
🇨🇱Valdivia, Los Rios, Chile
Centre Hospitalier Louis Pasteur ( Site 1360)
🇫🇷Le Coudray, Eure-et-Loir, France
CHD Vendee ( Site 1361)
🇫🇷La Roche-sur-Yon, Vendee, France
Universitaetsklinikum Heidelberg-Klinik für Kardiologie, Angiologie und Pneumologie ( Site 1475)
🇩🇪Heidelberg, Baden-Wurttemberg, Germany
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1874)
🇭🇺Szeged, Csongrad, Hungary
Medifarma 98 Kft-Outpatient Clinic ( Site 1859)
🇭🇺Nyiregyhaza, Hungary
Shaare Zedek Medical Center-Cardiology ( Site 2055)
🇮🇱Jerusalem, Israel
Yonsei University-Wonju Severance Christian Hospital ( Site 3555)
🇰🇷Wonju, Kang-won-do, Korea, Republic of
Chonnam National University Hospital ( Site 3558)
🇰🇷Gwangju-si, Kwangju-Kwangyokshi, Korea, Republic of
Pusan National University Hospital-Internal Medicine ( Site 3553)
🇰🇷Busan, Pusan-Kwangyokshi, Korea, Republic of
Chungnam national university hospital ( Site 3554)
🇰🇷Jung-gu, Taejon-Kwangyokshi, Korea, Republic of
Oaxaca Site Management Organization ( Site 2459)
🇲🇽Oaxaca, Mexico
Waikato Hospital-Cardiology Clinical Trials Unit ( Site 2654)
🇳🇿Hamilton, Waikato, New Zealand
Hutt Valley District Health board HVDHB-Cardiology Research Unit ( Site 2652)
🇳🇿Lower Hutt, Wellington, New Zealand
Research and Cardiovascular Corp. ( Site 3152)
🇵🇷Ponce, Puerto Rico
Private Practice - Dr. Lakatos Ferenc ( Site 1854)
🇭🇺Békéscsaba, Bekes, Hungary
Szent Rókus Kórház ( Site 1858)
🇭🇺Budapest, Hungary
Fundación Cardiovascular de Colombia ( Site 0961)
🇨🇴Piedecuesta, Santander, Colombia
Centre Hospitalier Régional Universitaire de Nancy - Hôpitau-Centre Investigation Clinique Plurithé
🇫🇷Vandoeuvre lès Nancy, Lorraine, France
Kardiologische Gemeinschaftspraxis ( Site 1460)
🇩🇪Nuremberg, Bayern, Germany
Kliniken Maria Hilf-Klinik für Kardiologie ( Site 1454)
🇩🇪Mönchengladbach, Nordrhein-Westfalen, Germany
Klinikum Ludwigshafen ( Site 1456)
🇩🇪Ludwigshafen, Rheinland-Pfalz, Germany
Konstantopoulio General Hospital-Cardiology Clinic ( Site 1553)
🇬🇷Athens, Attiki, Greece
Herzzentrum Dresden GmbH Universitätsklinik ( Site 1469)
🇩🇪Dresden, Sachsen, Germany
General Hospital of Athens Hippokratio ( Site 1552)
🇬🇷Athens, Attiki, Greece
Alexandra Hospital-HEART FAILURE AND CARDIO-ONCOLOGY UNIT ( Site 1559)
🇬🇷Athina, Attiki, Greece
Hospital Sultanah Nur Zahirah-Jabatan Perubatan ( Site 2360)
🇲🇾Kuala Terengganu, Terengganu, Malaysia
Hygeia Hospital-6th cardiology clinic ( Site 1560)
🇬🇷Marousi, Attiki, Greece
Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Cardiology ( Site 1878)
🇭🇺Gyula, Bekes, Hungary
CMed Rehabilitacios es Diagnosztikai Kozpont ( Site 1877)
🇭🇺Székesfehérvár, Szekesfehervar, Hungary
Tolna Megyei Balassa János Kórház ( Site 1868)
🇭🇺Szekszárd, Szekszard, Hungary
OEC Clinical Research - Zalaegerszeg ( Site 1864)
🇭🇺Zalaegerszeg, Hungary
Rambam Health Care Campus-Cardiology ( Site 2053)
🇮🇱Haifa, Israel
Sheba Medical Center-Leviev Heart Center ( Site 2064)
🇮🇱Ramat Gan, Israel
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 2151)
🇮🇹Bergamo, Italy
University of Perugia ( Site 2164)
🇮🇹Perugia, Italy
University Hospital of Alexandroupolis-First Department of Internal Medicine ( Site 1551)
🇬🇷Alexanroupolis, Evros, Greece
DRC Gyógyszervizsgáló Központ ( Site 1869)
🇭🇺Balatonfüred, Veszprem, Hungary
Yitzhak Shamir Medical Center-Cardiology ( Site 2060)
🇮🇱Zerifin, Israel
Cattinara Hospital-Cardiovascular Department ( Site 2162)
🇮🇹Trieste, Friuli-Venezia Giulia, Italy
IRCCS San Raffaele Pisana-riabilitazione cardiologica ( Site 2156)
🇮🇹Rome, Roma, Italy
Unidad Médica para la Salud Integral ( Site 2472)
🇲🇽San Nicolás de los Garza, Nuevo Leon, Mexico
Clínica Belén ( Site 2858)
🇵🇪Piura, Peru
Caparra Internal Medicine ( Site 3155)
🇵🇷Rio Grande, Puerto Rico
Krasnodar Regional Clinical Hospital Number 1 S.V. Ochapovskogo ( Site 3281)
🇷🇺Krasnodar, Krasnodarskiy Kray, Russian Federation
State budgetary Healthcare Institution of the city of Moscow "V. V. Vinogradov City Clinical Hospita
🇷🇺Moscow, Moskva, Russian Federation
Rostov State Medical University ( Site 3259)
🇷🇺Rostov-on-Don, Rostovskaya Oblast, Russian Federation
Pokrovskaya Municipal Hospital ( Site 3252)
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Astarta Clinic ( Site 3276)
🇷🇺Saint-Petersburg, Sankt-Peterburg, Russian Federation
Azienda Ospedaliero Universitaria S.Anna ( Site 2152)
🇮🇹Cona, Emilia-Romagna, Italy
Queen Mary Hospital-Medicine - Cardiology ( Site 1752)
🇭🇰Hksar, Hong Kong
Galilee Medical Center-Cardiology ( Site 2051)
🇮🇱Nahariya, Israel
IRCCS - AOU di Bologna-Dept. of Medical and Surgical sciences ( Site 2158)
🇮🇹Bologna, Italy
Chungbuk National University Hospital-Internal medicine ( Site 3551)
🇰🇷Cheongju-si, Chungbuk, Korea, Republic of
Gachon University Gil Medical Center ( Site 3559)
🇰🇷Namdong-gu, Incheon, Korea, Republic of
CIMAB SA de CV ( Site 2456)
🇲🇽Torreon, Coahuila, Mexico
Centro de Atención e Investigación Cardiovascular del Potosí ( Site 2453)
🇲🇽San Luis Potosí, San Luis Potosi, Mexico
Auckland City Hospital ( Site 2659)
🇳🇿Auckland, New Zealand
Clínica Javier Prado ( Site 2853)
🇵🇪Lima, Peru
NZOZ Twoja Przychodnia ( Site 3051)
🇵🇱Lublin, Lubelskie, Poland
ETG Warszawa ( Site 3052)
🇵🇱Warszawa, Mazowieckie, Poland
Private Practice - Dr. Yolanda Figueroa-Torres ( Site 3156)
🇵🇷Humacao, Puerto Rico
Hospital Angeles Xalapa ( Site 2451)
🇲🇽Xalapa-Enríquez, Veracruz, Mexico
Consultorio de Medicina Especilizada del Sector Privado ( Site 2455)
🇲🇽Xalapa, Veracruz, Mexico
Medical Care and Research SA de CV ( Site 2461)
🇲🇽Merida, Yucatan, Mexico
Centro de Investigacion Clinica de Oaxaca ( Site 2457)
🇲🇽Oaxaca, Mexico
Dunedin Hospital-Cardiology Department ( Site 2653)
🇳🇿Dunedin, Otago, New Zealand
Clínica Providencia ( Site 2856)
🇵🇪Lima, Peru
Hospital Cayetano Heredia-Servicio de cardiologia ( Site 2852)
🇵🇪Lima, Peru
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 2468)
🇲🇽Ciudad Madero, Tamaulipas, Mexico
Praktyka Lekarska Lidia Pawlowicz ( Site 3053)
🇵🇱Torun, Kujawsko-pomorskie, Poland
Private Practice - Dr. Robert Witek-Ośrodek Badań Klinicznych "METABOLICA" Lek. Robert Witek ( Site
🇵🇱Tarnów, Malopolskie, Poland
Centrum Medyczne Medyk ( Site 3065)
🇵🇱Rzeszow, Podkarpackie, Poland
Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman
🇵🇱Gdynia, Pomorskie, Poland
VA Caribbean Healthcare System ( Site 3157)
🇵🇷San Juan, Puerto Rico
Ivanovo Regional Healthcare Institution Cardiology Dispensary ( Site 3265)
🇷🇺Ivanovo, Ivanovskaya Oblast, Russian Federation
Perm Regional Hospital for War Veterans ( Site 3272)
🇷🇺Perm, Permskiy Kray, Russian Federation
Rostov-on-Don City Emergency Hospital ( Site 3271)
🇷🇺Rostov-on-Don, Rostovskaya Oblast, Russian Federation
Ryazan State Medical University named after Academician I.P. Pavlova ( Site 3260)
🇷🇺Ryazan, Ryazanskaya Oblast, Russian Federation
First Pavlov State Medical University of Saint Petersburg ( Site 3288)
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Volgograd State Medical University ( Site 3258)
🇷🇺Volgograd, Volgogradskaya Oblast, Russian Federation
National University Heart Centre, Singapore-Department of Cardiology ( Site 3355)
🇸🇬Singapore, South West, Singapore
Kaohsiung Medical University Hospital ( Site 3856)
🇨🇳Kaohsiung, Taiwan
MNE " Kyiv City Clinical Emergency Hospital" of Kyiv Regional Council (KCSA) ( Site 4256)
🇺🇦Kyiv, Ukraine
West Cumberland Hospital ( Site 4176)
🇬🇧Whitehaven, Cumbria, United Kingdom
Communal non-profit enterprise "Cherkasy Regional Hospital of Сherkasy Regional Council" ( Site 4292
🇺🇦Cherkasy, Cherkaska Oblast, Ukraine
St. George's Hospital-Cardiology Clinical Academic Group ( Site 4156)
🇬🇧London, England, United Kingdom
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 42
🇺🇦Odesa, Odeska Oblast, Ukraine
First Pavlov State Medical University of Saint Petersburg-Сardiology department ( Site 3257)
🇷🇺Saint Petersburg, Leningradskaya Oblast, Russian Federation
Almazov National Medical Research Centre ( Site 3320)
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Pokrovskaya Municipal Hospital-1-st cardiology department ( Site 3251)
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Institute for Medical Research ( Site 3316)
🇷🇺Sankt-Peterburg, Russian Federation
State Institution National Scientific Center M.D. Strazhesko-Essential Hypertension ( Site 4259)
🇺🇦Kyiv, Kyivska Oblast, Ukraine
Communal Non-profit Enterprise "City Hospital #6" Zaporizhzhia City Counci-Therapy department ( Site
🇺🇦Zaporizhia, Zaporizka Oblast, Ukraine
Clinical Hospital S.R.Mirotvortseva name SSMU ( Site 3254)
🇷🇺Saratov, Saratovskaya Oblast, Russian Federation
Chang Gung Medical Foundation-Linkou Branch ( Site 3854)
🇨🇳Taoyuan, Taiwan
Ankara Bilkent Şehir Hastanesi-cardiology ( Site 4053)
🇹🇷Ankara, Turkey
Central clinical hospital - Ukrzalisnytsia-2nd Cardiology ( Site 4306)
🇺🇦Kharkiv, Kharkivska Oblast, Ukraine
Clinical medical and diagnostic center Limited Liability Company "Simedgroup" ( Site 4284)
🇺🇦Івано-Франківськ, Ivano-Frankivska Oblast, Ukraine
Excellentis Clinical Trial Consultants ( Site 3464)
🇿🇦George, Western Cape, South Africa
Interregional Clinical Diagnostic Center-Department of Clinical Trials ( Site 3307)
🇷🇺Kazan, Tatarstan, Respublika, Russian Federation
Mackay Memorial Hospital-Hsinchu ( Site 3852)
🇨🇳Hsinchu City, Hsinchu, Taiwan
State Institution National Scientific Center M.D. Strazhesko-Department of clinical arrhythmology a
🇺🇦Kyiv, Ukraine
Walsall Manor Hospital ( Site 4179)
🇬🇧West Midlands, Walsall, United Kingdom
Cherkasy Regional Hospital-Cardiorheumatology ( Site 4283)
🇺🇦Cherkasy, Cherkaska Oblast, Ukraine
Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain
🇺🇦Kiev, Kyiv, Ukraine
Tiervlei Trial Centre ( Site 3461)
🇿🇦Bellville, Cape Town, Western Cape, South Africa
Medical Center of Limited Liability Company "Medical Center "Consilium Medical" ( Site 4257)
🇺🇦Kiev, Kyiv, Ukraine
Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 4064)
🇹🇷Antalya, Turkey
Başkent Üniversitesi Istanbul Hastanesi ( Site 4057)
🇹🇷Istanbul, Turkey
Medbud Clinic ( Site 4265)
🇺🇦Kyiv, Kyivska Oblast, Ukraine
Chesterfield Royal Hospital ( Site 4159)
🇬🇧Calow Chesterfield, Derbyshire, United Kingdom
Paarl Research Centre ( Site 3468)
🇿🇦Paarl, Western Cape, South Africa
Craigavon Area Hospital ( Site 4162)
🇬🇧Belfast, Northern Ireland, United Kingdom
Khmelnytskyi Regional Cardiovascular Center-department of invasive cardiology and interventional ra
🇺🇦Khmelnytskyi, Khmelnytska Oblast, Ukraine
Ukrayins'kyy Derzhavnyy Naukovo-Doslidnyy Instytut Rebilitatsiyi Invalidiv ( Site 4274)
🇺🇦Vinnytsia, Vinnytska Oblast, Ukraine
Lutsk City Clinical Hospital-Center for Cardiovascular Disease ( Site 4255)
🇺🇦Lutsk, Volynska Oblast, Ukraine
Ulster Hospital ( Site 4185)
🇬🇧Belfast, Lisburn And Castlereagh, United Kingdom
Worcestershire Royal Hospital-Cardiology Research Department ( Site 4181)
🇬🇧Worcester, Worcestershire, United Kingdom
Amager Hospital ( Site 1163)
🇩🇰CPH, Hovedstaden, Denmark
Nordsjællands Hospital - Hillerød ( Site 1159)
🇩🇰Hillerod, Hovedstaden, Denmark
Aarhus Universitetshospital, Skejby ( Site 1160)
🇩🇰Aarhus, Midtjylland, Denmark
Regionshospitalet Viborg ( Site 1166)
🇩🇰Viborg, Midtjylland, Denmark
Heart Center Research, LLC ( Site 0156)
🇺🇸Huntsville, Alabama, United States
VA West Los Angeles Medical Center-Cardiology ( Site 0149)
🇺🇸Los Angeles, California, United States
Cardiovascular Consultants of South Georgia, LLC ( Site 0137)
🇺🇸Thomasville, Georgia, United States
Erie County Medical Center ( Site 0160)
🇺🇸Buffalo, New York, United States
Southeastern Cardiology and Cardiovascular-Duke HC CRU - Lumberton ( Site 0134)
🇺🇸Lumberton, North Carolina, United States
New York Presbyterian Medical Group Hudson Valley Cardiology ( Site 0127)
🇺🇸Cortlandt Manor, New York, United States
Icahn School of Medicine at Mount Sinai ( Site 0161)
🇺🇸New York, New York, United States
Doylestown Hospital-Cardiology ( Site 0030)
🇺🇸Doylestown, Pennsylvania, United States
Southwest Family Medicine Associates ( Site 0131)
🇺🇸Dallas, Texas, United States
Clinica Medica ( Site 1651)
🇬🇹Guatemala, Guatemala
Valley Clinical Trials, Inc. ( Site 0085)
🇺🇸Covina, California, United States
Mercy Gilbert Medical Center-Dignity Health Cardiology ( Site 0075)
🇺🇸Gilbert, Arizona, United States
Excel Medical Clinical Trials ( Site 0008)
🇺🇸Boca Raton, Florida, United States
Valley Clinical Trials Inc ( Site 0006)
🇺🇸Northridge, California, United States
IACT Health ( Site 0106)
🇺🇸Columbus, Georgia, United States
Emory University School of Medicine ( Site 0123)
🇺🇸Atlanta, Georgia, United States
Mount Sinai Hospital ( Site 0050)
🇺🇸Chicago, Illinois, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0010)
🇺🇸Torrance, California, United States
Blue Coast Research Center ( Site 0053)
🇺🇸Vista, California, United States
Universal Axon Clinical Research, LLC ( Site 0022)
🇺🇸Doral, Florida, United States
Indago Research and Health Center Inc ( Site 0011)
🇺🇸Hialeah, Florida, United States
Chicago Medical Research ( Site 0086)
🇺🇸Hazel Crest, Illinois, United States
Alliance for Multispecialty Research, LLC ( Site 0143)
🇺🇸Wichita, Kansas, United States
The Heart Center of Lake County Research Institute-Research ( Site 0147)
🇺🇸Merrillville, Indiana, United States
Methodist Medical Center of Illinois ( Site 0098)
🇺🇸Peoria, Illinois, United States
Reid Physician Associates ( Site 0054)
🇺🇸Richmond, Indiana, United States
Accellacare - Wilmington ( Site 0090)
🇺🇸Wilmington, North Carolina, United States
South Texas Cardiovascular Consultants, PLLC-Research ( Site 0024)
🇺🇸Kerrville, Texas, United States
St. Louis Heart and Vascular, P.C.-Clinical Trials Unit ( Site 0029)
🇺🇸Saint Louis, Missouri, United States
Washington University-Department of Medicine ( Site 0044)
🇺🇸Saint Louis, Missouri, United States
University of Cincinnati Medical Center-Cardiology ( Site 0071)
🇺🇸Cincinnati, Ohio, United States
University of Missouri Hospital ( Site 0163)
🇺🇸Columbia, Missouri, United States
Aultman Hospital-Cardiology Clinical Trials ( Site 0064)
🇺🇸Canton, Ohio, United States
Centro Médico Viamonte-Clinical Research ( Site 4361)
🇦🇷Buenos Aires, Caba, Argentina
The Prince Charles Hospital-Cardiology Research Centre ( Site 0451)
🇦🇺Brisbane, Queensland, Australia
Carient Heart & Vascular - Manassas ( Site 0059)
🇺🇸Manassas, Virginia, United States
Core Research Group ( Site 0452)
🇦🇺Brisbane, Queensland, Australia
MultiCare Health System-MultiCare Cardiology - Inland Northwest ( Site 0102)
🇺🇸Spokane, Washington, United States
St. John of God Subiaco Hospital ( Site 0457)
🇦🇺Subiaco, Western Australia, Australia
Klinik Floridsdorf-Karl Landsteiner Institute for Cardiovascular and Critical Care Research c/o Dep
🇦🇹Wien, Austria
Universidade Federal de Goias-Serviço de Cardiologia ( Site 0553)
🇧🇷Goiania, Goias, Brazil
CAPED Centro Avancado Pesquisa e Diagnostica ( Site 0552)
🇧🇷Ribeirao Preto, Sao Paulo, Brazil
Hospital de Messejana Dr Carlos Alberto Studart Gomes ( Site 0560)
🇧🇷Fortaleza, Ceara, Brazil
Instituto de Pesquisa clinica de Campinas ( Site 0551)
🇧🇷Campinas, Sao Paulo, Brazil
Incor - Instituto do Coracao ( Site 0557)
🇧🇷Sao Paulo, Brazil
Corcare-Corcare Cardiovascular Research ( Site 0660)
🇨🇦Toronto, Ontario, Canada
Oakville Cardiovascular Research LP ( Site 0657)
🇨🇦Oakville, Ontario, Canada
Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0752)
🇨🇱Temuco, Araucania, Chile
North York Diagnostic and Cardiac Centre ( Site 0682)
🇨🇦North York, Ontario, Canada
IC La Serena Research ( Site 0769)
🇨🇱La Serena, Coquimbo, Chile
Shanghai Tongji Hospital-Cardiovascular Department ( Site 0905)
🇨🇳Shanghai, Shanghai, China
Anhui Provincil Hospital South District ( Site 0920)
🇨🇳Hefei, Anhui, China
Changsha Central Hospital ( Site 0854)
🇨🇳Changsha, Hunan, China
Medicus MFC Research Clinic ( Site 0676)
🇨🇦Toronto, Ontario, Canada
Shaanxi provincial people's hospital ( Site 0853)
🇨🇳Xian, Shaanxi, China
The People's Hospital of Liaoning Province ( Site 0859)
🇨🇳Shenyang, Liaoning, China
ONCOCENTRO APYS ( Site 0770)
🇨🇱Viña del Mar, Valparaiso, Chile
Chongqing Three Gorges Central Hospital ( Site 0913)
🇨🇳Wanzhou, Chongqing, China
Aero Space Center Hospital ( Site 0918)
🇨🇳Beijing, Beijing, China
Beijing Tsinghua Changgung Hospital ( Site 0911)
🇨🇳Beijing, Beijing, China
The Affiliated Hospital of Xuzhou Medical College ( Site 0910)
🇨🇳Xuzhou, Jiangsu, China
The Second Affiliated Hospital Chongqing Medical University-Department of Cardiology ( Site 0908)
🇨🇳Chongqing, Chongqing, China
Guangdong Provincial People's Hospital-Cardiology ( Site 0852)
🇨🇳Guangzhou, Guangdong, China
The First Affiliated Hospital of Jinan University ( Site 0897)
🇨🇳Guangzhou, Guangdong, China
Beijing Friendship Hospital-Cardology ( Site 0865)
🇨🇳Beijing, Beijing, China
Lanzhou university second hospital-Lanzhou university second hospital ( Site 0863)
🇨🇳Lanzhou, Gansu, China
The First People's Hospital of Foshan ( Site 0898)
🇨🇳Foshan, Guangdong, China
The University of Hong Kong - Shenzhen Hospital-Cardiovascular department ( Site 0895)
🇨🇳Shenzhen, Guangdong, China
Wuhan Union Hospital ( Site 0919)
🇨🇳Wuhan, Hubei, China
The Third Xiangya Hospital of Central South University-Cardiology ( Site 0860)
🇨🇳Changsha, Hunan, China
BAO TOU CENTRAL HOSPITAL ( Site 0866)
🇨🇳Bao Tou, Inner Mongolia, China
Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 0917)
🇨🇳Zhenjiang, Jiangsu, China
The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 0900)
🇨🇳Nanjing, Jiangsu, China
China-Japan Union Hospital-department of cardiology ( Site 0916)
🇨🇳Changchun, Jilin, China
Zhongshan Hospital,Fudan University-Cardiology ( Site 0851)
🇨🇳Shanghai, Shanghai, China
Corazon IPS ( Site 0964)
🇨🇴Barranquilla, Atlantico, Colombia
KIGE ( Site 1060)
🇨🇿Znojmo, Czechia
Fundación Centro de Investigación Clínica CIC ( Site 0955)
🇨🇴Medellín, Antioquia, Colombia
Shanghai Jiaotong University School of Medicine Ruijin Hospital-Cardiology Department ( Site 0855)
🇨🇳Shanghai, Shanghai, China
IPS Médicos Internistas de Caldas ( Site 0959)
🇨🇴Manizales, Caldas, Colombia
Centro de Investigaciones Clinicas SAS ( Site 0957)
🇨🇴Cali, Valle Del Cauca, Colombia
Clínica Imbanaco S.A.S ( Site 0963)
🇨🇴Cali, Valle Del Cauca, Colombia
Fakultní nemocnice Brno Bohunice-Interni kardiologicka klinika ( Site 1058)
🇨🇿Brno, Brno-mesto, Czechia
Rigshospitalet-Cardiology ( Site 1161)
🇩🇰Copenhagen, Hovedstaden, Denmark
Herlev and Gentofte Hospital-Department of Cardiology ( Site 1158)
🇩🇰Hellerup, Hovedstaden, Denmark
Hvidovre Hospital-259 ( Site 1151)
🇩🇰Hvidovre, Hovedstaden, Denmark
Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1156)
🇩🇰Svendborg, Syddanmark, Denmark
Vseobecna fakultni nemocnice v Praze-Centrum srdečního selhání ( Site 1059)
🇨🇿Praha 2, Czechia
CHU Charles Nicolle ( Site 1354)
🇫🇷Rouen, Haute-Normandie, France
Pitie Salpetriere University Hospital ( Site 1363)
🇫🇷Paris, Ile-de-France, France
Roskilde Sygehus ( Site 1162)
🇩🇰Roskilde, Sjaelland, Denmark
Centre Hospitalier Universitaire de Nice - Hopital Pasteur-Service cardiologie ( Site 1353)
🇫🇷Nice, Alpes-Maritimes, France
Klinikum Frankfurt Höchst ( Site 1463)
🇩🇪Frankfurt, Hessen, Germany
St. Michael's Hospital ( Site 1955)
🇮🇪Dun Laoghaire, Dublin, Ireland
Medizinische Hochschule Hannover ( Site 1476)
🇩🇪Hannover, Niedersachsen, Germany
University Hospital of Ioannina-2nd Department of Cardiology ( Site 1554)
🇬🇷Ioannina, Dytiki Ellada, Greece
Unidad De Diagnostico Cardiologico ( Site 1652)
🇬🇹Guatemala City, Guatemala
Princess Margaret Hospital ( Site 1755)
🇭🇰Hong Kong, Hong Kong
Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 1851)
🇭🇺Budapest, Hungary
Marienhaus Klinikum St. Elisabeth Neuwied ( Site 1452)
🇩🇪Neuwied, Rheinland-Pfalz, Germany
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1556)
🇬🇷Chaidari, Attiki, Greece
University General Hospital of Larissa ( Site 1555)
🇬🇷Larissa, Thessalia, Greece
Unidad De Diagnostico Cardiologico ( Site 1654)
🇬🇹Guatemala, Guatemala
European Interbalkan Medical Center-2nd Department of Cardiology ( Site 1557)
🇬🇷Thessaloniki, Greece
Bacs-Kiskun Megyei Korhaz-I. Belgyógyászat - Kardiológia ( Site 1873)
🇭🇺Kecskemét, Bacs-Kiskun, Hungary
TaNa Med ( Site 1866)
🇭🇺Mosonmagyaróvár, Gyor-Moson-Sopron, Hungary
Flor Ferenc Hospital of Pest County-5th Department of Internal Medicine ( Site 1852)
🇭🇺Kistarcsa, Pest, Hungary
Hillel Yaffe Medical Center-Heart Institute ( Site 2058)
🇮🇱Hadera, Israel
Hadassah Medical Center-Heart Institute ( Site 2062)
🇮🇱Jerusalem, Israel
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-U.O.C. Cardiologia ( Site 2161)
🇮🇹Milano, Lombardia, Italy
Centro Cardiologico Monzino-Heart Failure Unit ( Site 2153)
🇮🇹Milano, Lombardia, Italy
UiTM Sungai Buloh Campus ( Site 2354)
🇲🇾Sungai Buloh, Selangor, Malaysia
North Shore Hospital-Cardiology Research ( Site 2656)
🇳🇿Auckland, New Zealand
ospedale le scotte ( Site 2163)
🇮🇹Siena, Toscana, Italy
Instituto Nacional de Cardiologia Ignacio Chavez ( Site 2454)
🇲🇽Mexico, Distrito Federal, Mexico
Middlemore Clinical Trials ( Site 2658)
🇳🇿Auckland, New Zealand
Hospital Tengku Ampuan Afzan ( Site 2353)
🇲🇾Kuantan, Pahang, Malaysia
Hospital Sultanah Bahiyah-Department of Cardiology ( Site 2355)
🇲🇾Alor Setar, Kedah, Malaysia
Severance Hospital, Yonsei University Health System ( Site 3552)
🇰🇷Seoul, Korea, Republic of
Centro de Imagen y Tecnología en Intervención Cardiovascular ( Site 2477)
🇲🇽Mexico City, Distrito Federal, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 2474)
🇲🇽Mexico City, Distrito Federal, Mexico
Hospital General de Acapulco ( Site 2469)
🇲🇽Acapulco, Guerrero, Mexico
Unidad biomedica avanzada monterrey ( Site 2462)
🇲🇽Monterrey, Nuevo Leon, Mexico
Centro de Estudios de Alta Especialidad de Sinaloa ( Site 2463)
🇲🇽Mazatlán, Sinaloa, Mexico
Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud ( Site 2855)
🇵🇪Jesús María, Lima, Peru
Clínica El Golf-Cardiologia ( Site 2857)
🇵🇪Lima, Peru
Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 3070)
🇵🇱Legnica, Dolnoslaskie, Poland
NZOZ Centrum Medyczne KERmed ( Site 3066)
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
Instytut Chorób Serca, Zakład Badań Klinicznych Chorób Układu Krążenia ( Site 3057)
🇵🇱Wrocaw, Dolnoslaskie, Poland
Polsko-Amerykańskie Kliniki Serca ( Site 3077)
🇵🇱Kedzierzyn-Kozle, Opolskie, Poland
City Hospital No. 4 ( Site 3269)
🇷🇺Sochi, Krasnodarskiy Kray, Russian Federation
Cooperativa De Facultad Medica Sanacoop-Instituto Sanacoop ( Site 3151)
🇵🇷Bayamon, Puerto Rico
Tan Tock Seng Hospital ( Site 3353)
🇸🇬Singapore, Central Singapore, Singapore
Universitas Private Hospital-Cardiology Research ( Site 3453)
🇿🇦Bloemfontein, Free State, South Africa
Chris Hani Baragwanath Academic Hospital ( Site 3455)
🇿🇦Soweto, Gauteng, South Africa
Lenasia Clinical Trial Centre - Johannesburg ( Site 3470)
🇿🇦Johannesburg, Gauteng, South Africa
Professor Ntsekhe Cardiology Clinic ( Site 3454)
🇿🇦Cape Town, Western Cape, South Africa
Hospital Germans Trias i Pujol ( Site 3664)
🇪🇸Badalona, Barcelona, Spain
Hospital Universitari de Bellvitge-Unitat Multidisciplinar d'Insuficiència Cardíaca Comunitària (UM
🇪🇸L'Hospitalet de Llobregat, Cataluna, Spain
CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 3666)
🇪🇸A Coruña, La Coruna, Spain
HOSPITAL CLINICO DE VALENCIA ( Site 3656)
🇪🇸Valencia, Valenciana, Comunitat, Spain
Hospital Universitari Vall d'Hebron ( Site 3659)
🇪🇸Barcelona, Spain
Taichung Veterans General Hospital ( Site 3855)
🇨🇳Taichung, Taiwan
Afyon Kocatepe Üniversitesi Tıp Fakültesi-Cardiology Department ( Site 4058)
🇹🇷Afyonkarahisar, Turkey
Hacettepe Universitesi ( Site 4061)
🇹🇷Ankara, Turkey
Taipei Veterans General Hospital-General Clinical Research Center ( Site 3851)
🇨🇳Taipei, Taiwan
Municipal Non-commercial Enterprise "Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Fr
🇺🇦Ivano-Frankivsk, Ivano-Frankivska Oblast, Ukraine
Carmel Medical Practice ( Site 4152)
🇬🇧Darlington, England, United Kingdom
Consultative - Diagnostic Centre of Pechersky District-Therapeutic department ( Site 4307)
🇺🇦Kyiv, Ukraine
Communal nonprofit enterprise "City Hospital #9" of Zaporizhzhia City Council ( Site 4251)
🇺🇦Zaporizhia, Zaporizka Oblast, Ukraine
State Institution National Scientific Center M.D. Strazhesko-Resuscitation and Intensive care ( Site
🇺🇦Kyiv, Ukraine
Prince Charles Hospital ( Site 4171)
🇬🇧Merthyr Tydfil, Great Britain, United Kingdom
William Harvey Heart Centre ( Site 4169)
🇬🇧London, London, City Of, United Kingdom
Falu Lasarett-Dep of Cardiology ( Site 3756)
🇸🇪Falun, Dalarnas Lan, Sweden
Sahlgrenska Universitetssjukhuset-Cardiology Research Unit ( Site 3753)
🇸🇪Gothenburg, Vastra Gotalands Lan, Sweden
Netcare Sunninghill Hospital ( Site 3457)
🇿🇦Johannesburg, Gauteng, South Africa
Midrand Medical Centre ( Site 3466)
🇿🇦Midrand, Gauteng, South Africa
Jongaie Research ( Site 3469)
🇿🇦Pretoria West, Gauteng, South Africa
University of Pretoria - Faculty of Health Sciences-CRU ( Site 3462)
🇿🇦Pretoria, Gauteng, South Africa
Clinical Trial Systems ( Site 3452)
🇿🇦Pretoria, Gauteng, South Africa
CHEAR Center LLC ( Site 0009)
🇺🇸Bronx, New York, United States
NSC Research ( Site 0068)
🇺🇸Johns Creek, Georgia, United States
Norton Healthcare-Norton Heart Specialist ( Site 0062)
🇺🇸Louisville, Kentucky, United States
University of Alabama at Birmingham - School of Medicine-Cardiology ( Site 0153)
🇺🇸Birmingham, Alabama, United States
Advanced Cardiovascular - Alexander City ( Site 0038)
🇺🇸Alexander City, Alabama, United States
East Coast Institute for Research, LLC ( Site 0047)
🇺🇸Jacksonville, Florida, United States
East Coast Institute for Research - St. Augustine ( Site 0016)
🇺🇸Saint Augustine, Florida, United States
OSF Healthcare Cardiovascular Institute ( Site 0122)
🇺🇸Peoria, Illinois, United States
Franciscan Physician Network - Indiana Heart Physicians ( Site 0087)
🇺🇸Indianapolis, Indiana, United States
University of Iowa ( Site 0005)
🇺🇸Iowa City, Iowa, United States
ProMedica Toledo Hospital-ProMedica Heart Failure Clinic ( Site 0061)
🇺🇸Toledo, Ohio, United States
Dallas VA Medical Center ( Site 0084)
🇺🇸Dallas, Texas, United States
Medresearch Inc ( Site 0043)
🇺🇸El Paso, Texas, United States
Tyler Cardiovascular Consultants ( Site 0039)
🇺🇸Tyler, Texas, United States
INOVA Fairfax Medical Campus ( Site 0136)
🇺🇸Falls Church, Virginia, United States
Sentara Norfolk General Hospital ( Site 0114)
🇺🇸Norfolk, Virginia, United States
Centro de Pesquisa Clinica do Coracao ( Site 0561)
🇧🇷Acaraju, Sergipe, Brazil
University Of Alberta Hospital ( Site 0669)
🇨🇦Edmonton, Alberta, Canada
PACE Cardiology ( Site 0675)
🇨🇦Newmarket, Ontario, Canada
Private Practice - Dr. James Cha ( Site 0655)
🇨🇦Oshawa, Ontario, Canada
Hospital y CRS El Pino ( Site 0763)
🇨🇱Santiago, Region M. De Santiago, Chile
Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 0856)
🇨🇳Beijing, Beijing, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Cardiology ( Site 0868)
🇨🇳Guangzhou, Guangdong, China
Hainan General Hospital ( Site 0894)
🇨🇳Haikou, Hainan, China
Wuxi People's Hospital-Cardiovascular Department ( Site 0870)
🇨🇳Wuxi, Jiangsu, China
Hunan Provincial People's Hospital ( Site 0857)
🇨🇳ChangSha, Hunan, China
Xiangya Hospital Central South University-Cardiological Department ( Site 0899)
🇨🇳Changsha, Hunan, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Cardiolggy
🇨🇳Nanjing, Jiangsu, China
Northern Jiangsu People's Hospital ( Site 0861)
🇨🇳Yangzhou, Jiangsu, China
Accellacare - Charleston ( Site 0141)
🇺🇸Charleston, South Carolina, United States
Tianjin Chest Hospital-Cardiology ( Site 0901)
🇨🇳Tianjin, Tianjin, China
Centro Cardiovascular Colombiano Clínica Santa María ( Site 0951)
🇨🇴Medellín, Antioquia, Colombia
MUDr. Libor Nechvatal s.r.o. , Kardiologie ( Site 1057)
🇨🇿Brno, Jihomoravsky Kraj, Czechia
Fakultni Nemocnice u sv. Anny v Brne-I. interni kardioangiologicka klinika ( Site 1066)
🇨🇿Brno, Jihomoravsky Kraj, Czechia
Klinika Dr. Pirka ( Site 1065)
🇨🇿Mladá Boleslav, Mlada Boleslav, Czechia
Vojenská Nemocnice Brno-Internal department ( Site 1055)
🇨🇿Brno, Brno-mesto, Czechia
Institut Klinicke a Experimentalni Mediciny-Klinika kardiologie ( Site 1052)
🇨🇿Prague, Praha 4, Czechia
Ustredni vojenska nemocnice-Oddeleni kardiologie ( Site 1054)
🇨🇿Praha, Praha 6, Czechia
Nemocnice Slany-Interna - kardiologicka ambulance ( Site 1063)
🇨🇿Slany, Stredocesky Kraj, Czechia
KardioBusak s.r.o. ( Site 1051)
🇨🇿Louny, Czechia
Sygehus Vendsyssel Hjoerring ( Site 1164)
🇩🇰Hjorring, Nordjylland, Denmark
Holbæk Sygehus-Cardiology ( Site 1152)
🇩🇰Holbaek, Sjaelland, Denmark
Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1153)
🇩🇰Slagelse, Sjaelland, Denmark
Sydvestjysk Sygehus Esbjerg-Hjertemedicinsk Projekt ( Site 1154)
🇩🇰Esbjerg, Syddanmark, Denmark
Centre Hospitalier intercommunal de Toulon La Seyne sur Mer ( Site 1352)
🇫🇷Toulon, Provence-Alpes-Cote-d Azur, France
Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1364)
🇫🇷Lyon, Rhone, France
Universitaetsklinikum Wuerzburg ( Site 1458)
🇩🇪Wuerzburg, Bayern, Germany
Universitätsmedizin Greifswald ( Site 1470)
🇩🇪Greifswald, Mecklenburg-Vorpommern, Germany
Klinikum Leverkusen ( Site 1453)
🇩🇪Leverkusen, Nordrhein-Westfalen, Germany
Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien ( Site 1477)
🇩🇪Dresden, Sachsen, Germany
AHEPA University General Hospital of Thessaloniki-1st Cardiology Clinic ( Site 1558)
🇬🇷Thessaloniki, Greece
Pécsi Tudományegyetem Klinikai Központ ( Site 1865)
🇭🇺Pécs, Baranya, Hungary
St. James's Hospital-Cardiology ( Site 1951)
🇮🇪Dublin, Ireland
Assuta Ashdod Medical Center-Cardiology ( Site 2063)
🇮🇱Ashdod, Israel
Rabin Medical Center-Cardiology - CHF ( Site 2052)
🇮🇱Petah-Tikva, Israel
Policlinico Umberto I ( Site 2166)
🇮🇹Roma, Lazio, Italy
Azienda Ospedaliera Spedali Civili di Brescia-Cardiology- Day Hospital ( Site 2154)
🇮🇹Brescia, Italy
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 2165)
🇮🇹Torino, Italy
Hallym University Sacred Heart Hospital-Cardiovascular center ( Site 3556)
🇰🇷Anyang-si, Kyonggi-do, Korea, Republic of
Seoul National University Hospital ( Site 3557)
🇰🇷Seoul, Korea, Republic of
University Malaya Medical Centre ( Site 2351)
🇲🇾Lembah Pantai, Kuala Lumpur, Malaysia
Centro de Investigacion Cardiovascular y Metabólica ( Site 2465)
🇲🇽Tijuana, Baja California, Mexico
Medivest Centro de Investigación Integral ( Site 2460)
🇲🇽Chihuahua City, Chihuahua, Mexico
Grupo Ollin Care ( Site 2476)
🇲🇽Pachuca, Hidalgo, Mexico
Fundación Cardiovascular de Aguascalientes A.C. ( Site 2473)
🇲🇽Aguascalientes, Mexico
Christchurch Heart Institute ( Site 2651)
🇳🇿Christchurch, Canterbury, New Zealand
SP ZOZ w Puławach- Oddział Kardiologii ( Site 3071)
🇵🇱Pulawy, Lubelskie, Poland
Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 3062)
🇵🇱Chrzanow, Malopolskie, Poland
Centrum Medyczne Dr Sudnik s.c. Wanda i Jerzy Sudnik ( Site 3073)
🇵🇱Sokolka, Podlaskie, Poland
Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Sp. J. ( Site 3061)
🇵🇱Krakow, Malopolskie, Poland
Omsk Regional Clinical Health Service Number 9 ( Site 3296)
🇷🇺Omsk, Omskaya Oblast, Russian Federation
National Heart Centre Singapore ( Site 3351)
🇸🇬Singapore, Central Singapore, Singapore
Changi General Hospital ( Site 3356)
🇸🇬Singapore, South East, Singapore
Hospital Quiron Barcelona ( Site 3655)
🇪🇸Barcelona, Cataluna, Spain
TREAD Research ( Site 3451)
🇿🇦Cape Town, Western Cape, South Africa
Hospital Universitario Ramón y Cajal ( Site 3662)
🇪🇸Madrid, Madrid, Comunidad De, Spain
CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 3651)
🇪🇸Santiago de Compostela, La Coruna, Spain
Hospital Clinico San Carlos-Cardiology ( Site 3661)
🇪🇸Madrid, Spain
Parc de Salut Mar - Hospital del Mar ( Site 3663)
🇪🇸Barcelona, Spain
Hospital Universitario Virgen de Valme ( Site 3654)
🇪🇸Sevilla, Spain
Clemenstorgets Hjartmottagning ( Site 3755)
🇸🇪Lund, Skane Lan, Sweden
Karolinska Universitetssjukhuset Solna-Heart and Vascular theme ( Site 3759)
🇸🇪Solna, Stockholms Lan, Sweden
Universitetssjukhuset Örebro-Heart-Lung-Physiology Clinic ( Site 3754)
🇸🇪Örebro, Orebro Lan, Sweden
Akardo Med Site ( Site 3763)
🇸🇪Stockholm, Stockholms Lan, Sweden
Aleris Specialistvård Sabbatsberg ( Site 3762)
🇸🇪Stockholm, Stockholms Lan, Sweden
Skellefteå Lasarett-Research unit, floor 5 ( Site 3760)
🇸🇪Skellefteå, Vasterbottens Lan, Sweden
Västmanlands Sjukhus Västerås ( Site 3757)
🇸🇪Västerås, Vastmanlands Lan, Sweden
Changhua Christian Hospital ( Site 3857)
🇨🇳Changhua County, Changhua, Taiwan
Eskisehir Osmangazi University-Cardiology ( Site 4052)
🇹🇷Eskisehir, Turkey
Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 4063)
🇹🇷Istanbul, Turkey
Dokuz Eylül Üniversitesi-CARDIOLOGY ( Site 4055)
🇹🇷İzmir, Turkey
Medical Park zmir Hastanesi-cardiology ( Site 4059)
🇹🇷Izmir, Turkey
Mersin University ( Site 4056)
🇹🇷Mersin, Turkey
Kocaeli Üniversitesi-Cardiology ( Site 4060)
🇹🇷Kocaeli, Turkey
L.T. Mala National Institute of Therapy of NAMS of Ukraine-Clinical Pharmacology and Pharmacogeneti
🇺🇦Kharkiv, Kharkivska Oblast, Ukraine
Zakarpattya Regional Clinical Cardiology Dispensary-Dept. of Hospital Therapy, Uzhhorod National Un
🇺🇦Uzhgorod, Zakarpatska Oblast, Ukraine
Ninewells Hospital and Medical School-Cardiology ( Site 4164)
🇬🇧Dundee, Dundee City, United Kingdom
Russells Hall Hospital ( Site 4153)
🇬🇧Dudley, England, United Kingdom
Layton Medical Centre ( Site 4184)
🇬🇧Blackpool, Lancashire, United Kingdom
Blackpool Victoria Hospital ( Site 4161)
🇬🇧Blackpool, United Kingdom
University Hospital Coventry & Warwickshire-Research & Development ( Site 4170)
🇬🇧Coventry, United Kingdom
University Hospital of North Tees ( Site 4172)
🇬🇧Stockton-On-Tees, United Kingdom
NSHA-QEII Health Sciences Centre-Dickson Bldg-Cardiology ( Site 0664)
🇨🇦Halifax, Nova Scotia, Canada
Hospital Universitario La Paz ( Site 3665)
🇪🇸Madrid, Spain
Dominion Medical Associates, Inc. ( Site 0089)
🇺🇸Richmond, Virginia, United States
Instituto Jalisciense de Metabolismo SC ( Site 2467)
🇲🇽Guadalajara, Jalisco, Mexico
Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente ( Site 2466)
🇲🇽Guadalajara, Jalisco, Mexico
Cardiocent de Guadalajara S.C. ( Site 2464)
🇲🇽Guadalajara, Jalisco, Mexico
Kawartha Cardiology Clinical Trials ( Site 0654)
🇨🇦Peterborough, Ontario, Canada
Hôpital de la Cité-de-la-Santé ( Site 0673)
🇨🇦Laval, Quebec, Canada
Instituto Del Corazón De Bucaramanga ( Site 0960)
🇨🇴Bucaramanga, Santander, Colombia
Municipal Non-Profit Enterprise -City clinical hospital No8 of Kharkiv city council ( Site 4278)
🇺🇦Kharkiv, Kharkivska Oblast, Ukraine
Cardiovascular Research of Northwest Indiana ( Site 0036)
🇺🇸Munster, Indiana, United States
Cambridge Medical Trials ( Site 0041)
🇺🇸Alexandria, Louisiana, United States
Louisiana Heart Center - Hammond ( Site 0004)
🇺🇸Hammond, Louisiana, United States
Capitol Cardiology Associates - Lanham Office-Maryland Research Centers ( Site 0167)
🇺🇸Lanham, Maryland, United States
Praxis Rankestrasse ( Site 1461)
🇩🇪Berlin, Germany
CoroMed ( Site 1867)
🇭🇺Pécs, Baranya, Hungary
Hospital Queen Elizabeth II ( Site 2359)
🇲🇾Kota Kinabalu, Sabah, Malaysia
Centro de investigacion Clínica Trujillo-Medical specialties ( Site 2860)
🇵🇪Trujillo, La Libertad, Peru
Cambridge Cardiac Care Centre ( Site 0658)
🇨🇦Cambridge, Ontario, Canada
Hopital Pierre-Le Gardeur ( Site 0674)
🇨🇦Terrebonne, Quebec, Canada
Communal non-profit enterprise "City Clinical Hospital # 27" of Kharkiv City Council ( Site 4262)
🇺🇦Kharkiv, Kharkivska Oblast, Ukraine
Clinica Alemana Osorno ( Site 0768)
🇨🇱Osorno, Los Lagos, Chile
Semmelweis University-Városmajori Szív- és Érgyógyászati Klinika ( Site 1855)
🇭🇺Budapest, Hungary
Princess of Wales Hospital ( Site 4178)
🇬🇧Bridgend, Wales, United Kingdom
Prince of Wales Hospital ( Site 1751)
🇭🇰Shatin, Hong Kong