Elucidating the pathogenesis of Sjogren's syndrome: Analysis of lower lipbiopsies

Not yet recruiting

• Conditions: dry mouth; Xerostomie; 10003816

• Registration Number: NL-OMON34623
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

Patients having a diagnostic lower lipbiopsie for evaluation xerostomia

Exclusion Criteria

None

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Obtained material will be used to elucidate primarily the B cel pathogenesis of<br /><br>Sjogren's syndrome. Using immunohistochemistry, RNA and protein analysis, the B<br /><br>cell receptor (BCR), T cell receptor (TCR), a B cell stimulating cytokine (A<br /><br>proliferation-inducing ligand, APRIL), and the interaction between different<br /><br>immune cell populations and cytokines will be studied.<br /><br>Whenever enough patientmaterial is obtained, we are also be able to study<br /><br>different subpopulations, based on extra-glandular manisfestations and the<br /><br>severity of salivary gland inflammation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>