Comparison of the Effects of Intrathecal Morphine and Ultrasound-Guided Bilateral Posterior Quadratus Lumborum Block on Postoperative Acute Pain in Cesarean Section: A Prospective, Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- Morphine consumption in the first 24 hours after surgery
研究概览
简要总结
In this study, it was aimed to evaluate the effects of intrathecal morphine and posterior quadratus lumborum block (QLB2) on postoperative acute pain scores and opioid consumption in the first 24 hours after cesarean section.
详细描述
Postoperative acute pain following a cesarean section is sharp, well-localized, and highly intense. An ideal pain management approach after a cesarean section should provide high-quality analgesia with minimal side effects and facilitate the mother's rapid return to daily activities. Different options for pain control include central blocks, peripheral blocks, and systemic medications.
Intrathecal morphine (ITM) administration is a widely used approach for post-cesarean pain management both globally and in our clinic. However, it can reduce patient satisfaction due to side effects such as nausea, vomiting, and itching. On the other hand, the Quadratus Lumborum Block (QLB), a type of peripheral block, has proven analgesic efficacy in controlling acute postoperative pain following a cesarean section. The aim of this study is to examine and compare the analgesic efficacy of intrathecal morphine (ITM) and Posterior Quadratus Lumborum in the management of acute postoperative pain after a cesarean section.
This study is a single-center, double-blind, prospective observational study.
Patients will be divided into 2 groups.
Group 1: The group receiving intrathecal morphine (ITM)
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnant for at least 37 weeks
- •Aged between 18 and 45
- •ASA (American Society of Anesthesiologists) physical status score II
- •Patient planned for elective cesarean section under spinal anesthesia
- •Patient receiving QLB-II block or intrathecal morphine
排除标准
- •ASA score of III or IV.
- •Planned cesarean section under general anesthesia.
- •Requirement for conversion to general anesthesia after failed spinal anesthesia.
- •Contraindication to spinal anesthesia and regional anesthesia techniques.
- •BMI greater than 35 kg/m².
- •History of opioid use disorder or opioid use for more than 4 weeks.
- •Inability to assess pain scores.
- •Pregnancies of less than 37 weeks gestation.
- •History of allergy to local anesthetics and systemic opioids.
- •Patient refusal
结局指标
主要结局
Morphine consumption in the first 24 hours after surgery
时间窗: Postoperative day 1
Morphine consumption in the first 24 hours will be measured by IV PCA. Patients will be able to request opioids via a PCA device when their NRS score is above 4
次要结局
- Postoperative nausea and vomiting (PONV) scores(Postoperative Day 1)
- Postoperative pain scores(Postoperative day 1)
- Postoperative pruritus score(Postoperative Day 1)
- The number of patient required rescue analgesic(Postoperative Day 1)
- Patients' satisfaction and quality of pain management(Postoperative Day 1)
研究者
BURHAN DOST
Doc. Dr
Ondokuz Mayıs University