The role of hydrogen sulfide (H2S) as a marker of diagnosis and control in respiratory diseases
Not Applicable
- Conditions
- - Bronchial asthma - Chronic obstructive pulmonary disease - Interstitial pneumonia - Bacterial pneumonia - Lung tuberculosis - Healthy volunteer
- Registration Number
- JPRN-UMIN000010509
- Lead Sponsor
- Department of Pulmonary Medicine, Fukushima Medical University, School of Medicine
- Brief Summary
Hydrogen sulfide in serum, sputum, exhaled gas may be useful biomarkers to detect neutrophilic airway inflammation in asthma and COPD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients with an indefinite diagnosis 2. Patients having severe complications 3. Pregnant women or breast feeding women 4. Patients who are unable to give informed consent 5. Inappropriate patients judged by respiratory physicians
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the hydrogen sulfide levels in various respiratory diseases.
- Secondary Outcome Measures
Name Time Method 1. To investigate the relationships between hydrogen sulfide levels and other conventional parameters such as pulmonary function, fractional exhaled nitric oxide (FeNO), St Georges Repiratory Questionnaire (SGRQ), and inflammatory cells in sputum. 2. To evaluate the relationships between the time course of hydrogen sulfide levels, severity and state of respiratory diseases.