Effects of Chronic Intake of Cannabis on Contrast Sensitivity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- The contrast detection treshold
研究概览
简要总结
Rates of driving under the influence of cannabis have risen in recent years. Cannabis is involved in 1/3 of motor vehicle collisions. The chronic use of cannabis is known to affect dopaminergic regulation and may thus impair contrast sensitivity. In turn, contrast sensitivity disorders could originate difficulties to anticipate and avoid collision with objects, especially when objects are in movement. The investigators goal is to examine the effects of a chronic intake of cannabis on contrast sensitivity. The observed values will be compared to standard references. In addition, since smoking cannabis is always associated with tobacco, the investigators will control the effects of tobacco on contrast sensitivity.
In this study, the investigators will include 36 cannabis addicts, 36 tobacco addicts and 36 no smokers. The investigators will present gratings with different spatial frequencies and the investigators will determine contrast thresholds for static and dynamic (moving) gratings. The investigators predict that cannabis addicts will present abnormal contrast sensitivity especially in case of dynamic presentation of gradings.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •"Cannabis" Arm
- •patient addicted to cannabis
- •Positive CAST test result
- •Urine tested positive for cannabis metabolites
- •"Tobacco" Arm
- •positive Fagerström test result
- •No cannabis intake in the last year before inclusion
- •No previous history of cannabis use
- •"Healthy Volunteers"
- •No tobacco or cannabis intake in the last year before inclusion
- •No history of addictive disorders
排除标准
- •addiction to other substances than cannabis or tobacco
- •benzodiazepine treatment
- •patient with history of benzodiazepine treatment
- •patient with history of general anesthesia in the last 3 months before inclusion
- •patient with history of head trauma
- •Pregnant woman
- •breast feeding woman
- •Adults under supervision or guardianship
研究组 & 干预措施
"Tobacco" Arm
patient addicted to tobacco
干预措施: contrast sensitivity tests (Other)
"Tobacco" Arm
patient addicted to tobacco
干预措施: electroretinogram (Other)
"Cannabis" Arm
patient addicted to cannabis
干预措施: electroretinogram (Other)
"Cannabis" Arm
patient addicted to cannabis
干预措施: contrast sensitivity tests (Other)
"Healthy volunteers"
no smokers
干预措施: electroretinogram (Other)
"Healthy volunteers"
no smokers
干预措施: contrast sensitivity tests (Other)
结局指标
主要结局
The contrast detection treshold
时间窗: up to 9 days after inclusion
Comparison of the contrast detection threshold of the 3 groups
次要结局
未报告次要终点