Pre-, peri- and post-operative complications in patients with brain metastases
- Conditions
- C79.3Secondary malignant neoplasm of brain and cerebral meninges
- Registration Number
- DRKS00019808
- Lead Sponsor
- niversitätsklinikum Essen, Klinik für Neurochirurgie und Wirbelsäulenchirurgie
- Brief Summary
This study emphasizes the safety of anticoagulation in patients with brain metastases and highlights the safety of neurosurgical treatment in patients with hemorrhagic brain metastases when blood-thinning medication is temporarily paused. The presence of intra-tumoral hemorrhage negatively impacts survival, highlighting its prognostic significance in brain metastases patients. Further research with larger cohorts is warranted to validate these findings and elucidate underlying mechanisms.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 229
Inclusion Criteria
(1) Radiographic detection of intracerebral metastases of extracranial origin.
(2) Surgical treatment in the recruiting department.
Exclusion Criteria
(1) Diseases of the lymphatic system.
(2) Insufficient access to clinical and imaging data.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluation of demographical, clinical, radiological, histological and molecular data in the context of disease progression and treatment complications. Treatment allocation and follow-up data is used for this study. Neuropathological analyses on the tumor specimen are necessary to receive histological and molecular data. Statistical analyses comprise univariate and multivariate analyses.
- Secondary Outcome Measures
Name Time Method Effectivity and eligibility of routinely applied treatment algorithms are analyzed in order to improve the treatment of future patients.