Validation of the falling stick test as screening test device for prodromal neurodegenerative diseases

Recruiting

• Conditions: G47.8; F06.7; Other sleep disorders; Mild cognitive disorder

• Registration Number: DRKS00030352
• Lead Sponsor: Hans Berger Klinik für Neurologie, Universitätsklinikum Jena

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 111

Inclusion Criteria

Group 1: Patients of any gender with idiopathic REM sleep behavior disorder (prodromal Parkinson's disease) without parkinsonoid movement deficits, Age >= 18 years

Group 2: Patients of any gender with amnestic Mild Cognitive Impairment (prodromal Alzheimer's disease), Age >= 18 years

Group 3: Healthy control participants of any gender, adapted for age and gender, Age >= 18 years

Exclusion Criteria

presence of a disease which could potentially impair the motor function or responsiveness, including the following:
- neurological diseases:
o history of stroke
o history of cerebral haemorrhage
o multiple sclerosis
o history of meningitis or encephalitis
o epilepsy
o chronic headache or migraine (duration > 3 months, minimum of 15 days per month)
o brain tumour
o pronounced polyneuropathy with impairment of the upper extremities
o neurodegenerative disease
-->Parkinson's disease
--> Alzheimer's disease or a different type of dementia
- presentation of a presently treated, oncological disease
- severe sight disorder that cannot be adjusted for by use of a visual aid
- presentation of a cardiological disease with impaired left or right ventricular pump function (NYHA III-IV)
- presentation of an orthopedic disease/injury/dysfunction that is ongoing or was present in the last 6 months, impairs the grip function and affects one or multiple of the following localisations:
o upper extremity (hand, finger, wrist, elbow)
o cervical spine
o thoracis spine
- centrally acting medication that possibly impairs the motor function or responsiveness

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcomes are the results of the falling stick test and are measured during the study visit:<br>-distance (in centimeters) the stick drops until it is touched/caught/stopped from falling<br>-grip force when the stick is caught/stopped from falling.