Effectiveness of Intraoperative Nitrous Oxide for Postoperative Pain in Lumbar Spinal Fusion Surgery: A Randomized Controlled Trial.
Not Applicable
Recruiting
- Conditions
- Postoperative pain
- Registration Number
- JPRN-UMIN000048817
- Lead Sponsor
- Keiyu Orthopedic Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Not provided
Exclusion Criteria
Due to trauma (fracture, nerve damage), not speaking Japanese, impaired consciousness (if difficult to assess). Complications of psychiatric disorders, history of blood disorders.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method low back pain and lower limb pain intensity (Numerical Rating Scale (NRS): 0-10) up to 48 hours postoperatively.
- Secondary Outcome Measures
Name Time Method (1) Postoperative numbness in the lower limb (numbness score: 0-3) (2) Dose of fentanyl by iv-PCA (3) Number of times of administration of adjuvant analgesics (4) Number of points of nausea and vomiting (5) Relationship between time to surgery and pain
Related Research Topics
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How does intraoperative nitrous oxide modulate NMDA receptor activity to reduce postoperative pain after lumbar fusion?
What is the comparative effectiveness of nitrous oxide versus opioids in managing postoperative pain after PLIF?
Which inflammatory biomarkers predict response to intraoperative nitrous oxide in lumbar spinal fusion patients?
What are the adverse event profiles of nitrous oxide compared to sevoflurane in spinal surgery anesthesia?
How does combining nitrous oxide with local anesthetics enhance postoperative analgesia in spinal fusion?