Cardiovascular Risk in Growth Hormone Deficient Young Adult Males After Completing Growth Hormone Therapy.

Children's Mercy Hospital Kansas City1 site in 1 country24 target enrollmentJune 2008

ConditionsGrowth Hormone Deficiency

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Growth Hormone Deficiency
Sponsor: Children's Mercy Hospital Kansas City
Enrollment: 24
Locations: 1
Primary Endpoint: Compare carotid artery intima medial thickness
Status: Completed
Last Updated: 17 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to compare the cardiovascular risks of growth hormone deficient young adult males who have completed growth hormone therapy to healthy young adult males.

Detailed Description

Adults with growth hormone deficiency are at risk for cardiovascular disease. What age this begins is not known. The objectives of this study are to compare the following measurements between growth hormone deficient young males 3-7 years post completion of growth hormone treatment and age related healthy controls: 1. Carotid artery imaging 2. Metabolic and cardiac parameters 3. Body composition measurements

Registry

clinicaltrials.gov

Start Date

June 2008

End Date

February 2009

Last Updated

17 years ago

Study Type

Observational

Sex

Male

Investigators

Sponsor

Children's Mercy Hospital Kansas City

Eligibility Criteria

Inclusion Criteria

•Males, 18-25 years old
•Completed growth hormone therapy approximately 3-5 years prior to study enrollment
•History of multiple pituitary hormone deficiencies or growth hormone stimulation test \<7 at initiation of growth hormone therapy
•Healthy Control Inclusion Criteria:
•Males, 18-25 years old
•No confirmed endocrine diagnosis including Diabetes and thyroid disorders
•BMI - z-score within 2 SD of mean

Exclusion Criteria

•Known risk factors for cardiovascular disease (eg tobacco use, hypertension, diabetes)
•Family history of early cardiovascular disease (myocardial infarction or stroke \<55years of age) in first degree family members
•Any implanted device
•Medication known to interfere with glucose or lipid metabolism or to influence blood pressure
•Chronic organ illness (eg severe asthma, hepatic or nephritic conditions)