NCT00711061已完成不适用
Cardiovascular Risk in Growth Hormone Deficient Young Adult Males After Completing Growth Hormone Therapy.
Children's Mercy Hospital Kansas City1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2008年6月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Compare carotid artery intima medial thickness
研究概览
简要总结
The purpose of this study is to compare the cardiovascular risks of growth hormone deficient young adult males who have completed growth hormone therapy to healthy young adult males.
详细描述
Adults with growth hormone deficiency are at risk for cardiovascular disease. What age this begins is not known.
The objectives of this study are to compare the following measurements between growth hormone deficient young males 3-7 years post completion of growth hormone treatment and age related healthy controls:
- Carotid artery imaging
- Metabolic and cardiac parameters
- Body composition measurements
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Males, 18-25 years old
- •Completed growth hormone therapy approximately 3-5 years prior to study enrollment
- •History of multiple pituitary hormone deficiencies or growth hormone stimulation test <7 at initiation of growth hormone therapy
- •Healthy Control Inclusion Criteria:
- •Males, 18-25 years old
- •No confirmed endocrine diagnosis including Diabetes and thyroid disorders
- •BMI - z-score within 2 SD of mean
排除标准
- •Known risk factors for cardiovascular disease (eg tobacco use, hypertension, diabetes)
- •Family history of early cardiovascular disease (myocardial infarction or stroke <55years of age) in first degree family members
- •Any implanted device
- •Medication known to interfere with glucose or lipid metabolism or to influence blood pressure
- •Chronic organ illness (eg severe asthma, hepatic or nephritic conditions)
结局指标
主要结局
Compare carotid artery intima medial thickness
时间窗: During study visit
次要结局
- Compare metabolic parameters and body composition measurements(During study visit)
研究者
研究点 (1)
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