The effect of neuromuscular electrical stimulation on post-prandial protein accretion during the day and prior to sleep

Completed

• Conditions: 10028302; loss of muscle mass; Sarcopenia; 10037008

• Registration Number: NL-OMON40767
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 28

Inclusion Criteria

- Age 65-85 years
- Male
- 18.5 * BMI * 30.0

Exclusion Criteria

- Type II diabetes
- All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery).
- Use of anticoagulants, blood diseases, allergy for lidocain
- Use of NSAIDs and acetylsalicylic acid
- Patients suffering from PKU (Phenylketonuria)
- Presence of implantable cardioverter defibrillator and/or pacemaker
- Performed regular resistance type exercise in the past 6 months
- Use of any tools to assist during walking (cane/ crutches/ walker)
- (Partial) foot/ leg amputation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>De novo muscle protein accretion, measured as enriched muscle protein [mole<br /><br>percent excess (MPE)].</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Plasma amino acid enrichment after ingestion of the intrinsically labeled<br /><br>protein</p><br>