Efficacy of Devdaru Kwath in reducing Blood Sugar as a Upshaya in Madhumeha ( Diabetes Mellitus ) A Pragmatic Randomized Control Trial

Madhumeha is the disease of metabolic derangement and genetic predisposition related with each individual body constitution and systemic consideration. In Ayurveda Madhumeha has been described as one among the 20 types of Prameha & is a sub-type of Vatika Prameha in which patient passes excessive amounts of urine that tastes & looks like honeyi.iiIn Madhumeha the properties of urine is similar with that of Madhu i.e. of Kashaya and Madhura rasa, rooksa (dry) guna and honey like colour. Madhumeha is well described in ayurvedic major and minor samhitas. Though it is a subtype of Vataja Prameha it has more prevalence in the society and may be compared to diabetes mellitus of the modern medical sciences .The main factors involved in the pathogenesis of Prameha are Vata, Pitta, Kapha, Meda and Oja. Therefore the treatment of this disease should be Tridosha shamaka chikitsa along with Brimhan-Karshana and Rasayana chikitsa. Acharya Sushurt has narrated that all the Pramehas finally convert into Madhumeha, if not treated at the primary stage.

Diabetes mellitus is a chronic, debilitating disease characterized by hyperglycemia, insulin resistance, and impaired insulin secretion. As per International Diabetes Federation’s (IDF) fifth diabetes atlas, India’s prevalence of diabetes among 20-79 year olds is 9.2%. India is just second to China. Due to increase in prevalance of Type-2 DM in society and day by day increasing incidence of primary and secondary drug failures, it would be effective to introduce a drug as Upshaya along with the standard prescription prescribed by the physician.According to Vachaspatyam Upshaya word is derived from Upa+Shi-Ach (Samipashayane). According to Vaidyaka sabdha sindhu Vyadhi jnana heto is Upshaya. Upshaya word involves the factors which bring about happiness (Sukhanubandha) either by acting directly against the cause of the disease or the disease itself. According to Amarakosha it indicates permanent relief but not temporary.

As Devdaru has properties opposite to that of Kapha and Vata dosha it would be effective in reducimg blood sugar as it is said to be Kaphavataghna , Bhavprakash Nighantu , Kaiyedev Nighantu, Dhanvantari Nighantu has mentioned Devdaru as Pramehaghna, So the study to evaluate the efficacy of Devdaru Kwath as a Upshaya without disturbing the standard treatment protocol would be very helpful to asses the hypoglycemic effect of Devdaru as an adjuncture therapy in the form of Upshaya.

There is no such study conducted which involves the assessment of Madhumehi patients on the basis of Upshaya. This study will help to analyze that whether Devdaru kwath as a Upshaya has hypoglycemic effect or not without disturbing the standard prescription prescribed by a physician.