Effect of perioperative fixed-dose dual bronchodilator therapy on post-operative pulmonary function among mild- to -moderate COPD patients undergoing lung cancer surgery
- Conditions
- Diseases of th respiratory system
- Registration Number
- KCT0005454
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 204
• Subjects of men or female over 40 years of age who are scheduled for curative pulmonary lobectomy due to confirmation (or high suspicion) of non-small cell lung cancer (NSCLC)
• Subjects waiting at least 14 days for scheduled pulmonary lobectomy
• Subjects who are newly diagnosed with COPD* or who have not used any bronchodilators within the past 3 months, even if they have previously been diagnosed with COPD
• COPD : Post-bronchodilator (Post-BD) FEV1/FVC <0.7 and Post-BD FEV1 =70 %predicted (%pred)
• Subjects with dyspnea of 0 or 1 grade measured by modified Medical Research Council (mMRC)
• Pregnancy: subjects of women who are pregnant, lactating, planning on becoming pregnant during the clinical trial, or of child bearing potential not using contraception methods
• COPD treatment/acute exacerbation: subjects who have been treated with COPD within the past 3 months or have experienced acute exacerbation of COPD within the past 1 month (Acute exacerbation of COPD is defined as the cases requiring antibiotics, oral corticosteroids, emergency treatment, or hospitalization due to at least one symptom from increased breathlessness, sputum volume, or sputum purulence)
• Other pulmonary diseases: subjects who are physician-diagnosed with asthma or Idiopathic Pulmonary Fibrosis (IPF)
• Lung cancer treatment: subjects who have been received neo-adjuvant treatment for lung cancer (chemotherapy, radiotherapy, or concurrent chemo-radiotherapy)
• Other diseases/abnormalities: subjects diagnosed with historical or current evidence of clinically significant cardiovascular, neurological, psychiatric, renal, hepatic, immunological, gastrointestinal, urogenital, nervous system, musculoskeletal, skin, sensory, endocrine (including uncontrolled diabetes or thyroid disease) or hematological abnormalities including medical condition corresponding to ‘warnings and precautions’ (such as coronary artery disease, acute myocardial infarction, cardiac arrhythmia, hypertension, convulsive disorders, thyrotoxicosis, hypokalemia, diabetes, narrow-angle glaucoma, urinary retention, prostatic hyperplasia, bladderneck obstruction etc.) that are uncontrolled and/or with cancer within 5 years (Significant is defined as any disease that, in the opinion of the Investigator, would put the safety of the subject at risk through participation, or which would affect the efficacy or safety analysis if the disease/condition exacerbated during the study.)
• Abnormal and clinically significant 12-Lead Eletrocardiogram (ECG): subjects with abnormal and clinically significant ECG findings (Significant is defined as any disease that, in the opinion of the Investigator, would put the safety of the subject at risk through participation, or which would affect the efficacy or safety analysis if the disease/condition exacerbated during
the study.)
• Contraindications: subjects with a history of allergy or hypersensitivity to any Long-Acting Muscarinic Antagonist (LAMA), Long-Acting Beta-Agonist (LABA), lactose/milk protein, stearic magnesium, with generic problems including galactose intolerance, Lapp lactose deficiency, or glucosegalactose malabsorption, or with contraindication of inhaled anticholinergiccontaining drugs
• Mobility: subjects who are not able to walk independently without mobility assistance or other people
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Post-bronchodilator FEV1 (ml) measured at 16 weeks postoperatively
- Secondary Outcome Measures
Name Time Method Postoperative pulmonary and cardiac complication;Length of hospital stay;COPD Acute exacerbation;Compliance;Dyspnea and health-related quality of life at postoperative 3 weeks : mMRC, CAT, BFI, SGRQ-C, EORTC-QLC C-30, LC-30, BDI/TDI;Dyspnea and health-related quality of life at postoperative 16 weeks : mMRC, CAT, BFI, SGRQ-C, EORTC-QLC C-30, LC-30, BDI/TDI;Difference of predicted postoperative FEV1 and actual postoperative FEV1 at 16 weeks postoperatively;Difference of post-bronchodilator FEV1 (ml) at baseline and post-bronchodilator FEV1 (ml) before surgery;Difference of post-bronchodilator FEV1 (ml) before surgery and post-bronchodilator FEV1 (ml) at 3 weeks postoperatively;Exercise tolerance at postoperative 3 weeks 6-minute walk test distance (meter);Exercise tolerance at postoperative 16 weeks 6-minute walk test distance (meter)