Effect of Camel Milk on Insulin and Incretin Response

Not Applicable

• Conditions: Glucose Tolerance; Insulin Sensitivity
• Interventions: Dietary Supplement: Cow milk; Dietary Supplement: Camel milk

• Registration Number: NCT03725969
• Lead Sponsor: Imperial College London Diabetes Centre

Brief Summary

To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance

Detailed Description

Camel milk is used as a traditional remedy throughout the Middle East and Indian Subcontinent for conditions such as type 2 diabetes and dyslipidemia. It is currently unclear how such an effect could be mediated in vivo and studies are limited. We performed this study as a pilot experiment to assess the effects of camel milk on Insulin, Glucose, GLP-1, C-peptide and Lipid profile.

Study Timeline

• Study Start: 2017-02-01
• Study First Submitted: 2018-10-14
• Study First Submitted QC: 2018-10-28
• Study First Posted: 2018-10-31
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-11
• Last Update Posted: 2020-02-12
• Primary Completion: 2020-12-30
• Study Completion: 2020-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Normal glucose tolerance
• BMI < 30 kg/m2

Exclusion Criteria

• Type 1 diabetes mellitus
• Type 2 diabetes mellitus
• Impaired fasting glucose or impaired glucose tolerance
• Lactose intolerance
• Weight loss / gain ≥ 5 kg in the preceding two months
• Use of estrogenic drugs or corticosteroids
• Known hypertriglyceridemia requiring treatment
• History of heart attack, angina or cardiovascular disorder
• History of malignant tumor
• Pregnant or lactating women
• Hemoglobin < 12 for any reason
• Recent surgery or major hemorrhage
• History of bariatric or metabolic surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Healthy individuals (cow milk)	Cow milk	-
Healthy individuals (camel milk)	Camel milk	-

Primary Outcome Measures

Name	Time	Method
Response of glucose to camel and cow milk	5 months	The difference between interventions in terms of area under the curve
Glucose response to camel and cow milk	5 months	The difference between interventions in terms of peak of glucose

Secondary Outcome Measures

Name	Time	Method
Response of GLP-1 to camel and cow milk	5 months	The difference between interventions in terms of area under the curve
Response of C-peptide to camel and cow milk	5 months	The difference between interventions in terms of area under the curve
Response of insulin to camel and cow milk	5 months	The difference between interventions in terms of area under the curve
Insulin response to camel and cow milk	5 months	The difference between interventions in terms of peak
GLP-1 response to camel and cow milk	5 months	The difference between interventions in terms of peak
C-peptide response to camel and cow milk	5 months	The difference between interventions in terms of peak

Trial Locations

Locations (1)

Imperial College London Diabetes Centre; 🇦🇪 Abu Dhabi, United Arab Emirates