The Effect of Camel Milk on Insulin and Incretin Response to a Mixed-meal Challenge in People With Normal Glucose Tolerance
试验速览
- 阶段
- 不适用
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Response of glucose to camel and cow milk
研究概览
简要总结
To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance
详细描述
Camel milk is used as a traditional remedy throughout the Middle East and Indian Subcontinent for conditions such as type 2 diabetes and dyslipidemia. It is currently unclear how such an effect could be mediated in vivo and studies are limited. We performed this study as a pilot experiment to assess the effects of camel milk on Insulin, Glucose, GLP-1, C-peptide and Lipid profile.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
盲法说明
Double-blind
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal glucose tolerance
- •BMI < 30 kg/m2
排除标准
- •Type 1 diabetes mellitus
- •Type 2 diabetes mellitus
- •Impaired fasting glucose or impaired glucose tolerance
- •Lactose intolerance
- •Weight loss / gain ≥ 5 kg in the preceding two months
- •Use of estrogenic drugs or corticosteroids
- •Known hypertriglyceridemia requiring treatment
- •History of heart attack, angina or cardiovascular disorder
- •History of malignant tumor
- •Pregnant or lactating women
- •Hemoglobin < 12 for any reason
- •Recent surgery or major hemorrhage
- •History of bariatric or metabolic surgery
结局指标
主要结局
Response of glucose to camel and cow milk
时间窗: 5 months
The difference between interventions in terms of area under the curve
Glucose response to camel and cow milk
时间窗: 5 months
The difference between interventions in terms of peak of glucose
次要结局
- Response of GLP-1 to camel and cow milk(5 months)
- Response of C-peptide to camel and cow milk(5 months)
- Response of insulin to camel and cow milk(5 months)
- Insulin response to camel and cow milk(5 months)
- GLP-1 response to camel and cow milk(5 months)
- C-peptide response to camel and cow milk(5 months)