Optimization and evaluation of modern MRI techniques for acceleration and artifact reduction in pathologies of the skull base

Conditions: isted exemplary ICH codes in an openly designed study, which covers a broader spectrum of skull base lesions: H.90.0 - H.90.8, H.91.0, H91.9, H93.8, H93.9, D33.1, D33.3, D33.7, D33.9, D32.9, D36.1, C.72.5

Registration Number: DRKS00024438

Lead Sponsor: Institut für Radiologie und Neuroradiologie Evangelisches Krankenhaus Oldenburg, Universitätsmedizin Oldenburg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 70

Inclusion Criteria

General: persons with a minimum age of 18 years who are able to give their informed consent

Subproject 1 and 2, Step 1: Healthy Volunteers

Subproject 1, Step 2: Patients for CI evaluation (screening MRI examination for the exclusion of abnormalities of the auditory nerves, inner ears and central auditory path)

Subproject 2, Step 2: Patients with known or suspected untreated skull base lesions (e.g. vestibular Schwannomas, pseudotumors of the orbit, paragangliomas)

Exclusion Criteria

General:
- General MRI contraindications for MRI, e.g. implants such as non-conditional MR-suitable pacemakers or auto-defibrillators, implanted neural stimulators and ocular metal foreign bodies (e.g. metal shards)
- Conditions that could hinder the conduct of the study (e.B. morbid obesity, pronounced claustrophobia)
- Existing unnecessary risks (pregnancy, surgery of an unsafe nature).

Subproject 1 and 2, Step 1: Known serious disease of the central nervous system.

Subproject 1, Step 2: Known serious disease of the central nervous system (other than possibly the one associated with hearing loss in the patient group).

Subproject 2, Step 2: Known serious disease of the central nervous system (except skull base lesions in the patient group)

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Subproject 1) Overall image quality of CI (cochlear implant) pre-diagnosis for the detection of relevant anatomical details:<br>Blind evaluations of MRI-experienced evaluators (doctors) when using the optimized T2 SPACE CS sequence compared to the CISS sequence. <br>Subproject 2) Overall image quality in delineation of skull-base lesions: blind evaluations by differently experienced (neuro-)radiologists (numerical 100-point scale).<br>

Secondary Outcome Measures