Research on key technologies for perioperative risk management and control of age-related diseases

Not Applicable

Completed

Conditions: Perioperative blood pressure management in elderly patients with hypertension
Circulatory System

Registration Number: ISRCTN18251692

Lead Sponsor: People's Hospital of Xinjiang Uygur Autonomous Region

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 1800

Inclusion Criteria

1. Elderly patients, aged 65-80 years old
2. Patients with a history of hypertension with systolic blood pressure =140mmHg and pulse pressure difference =60mmHg
3. No contraindications to anesthesia
4. No signs of systemic infection

Exclusion Criteria

1. Tumors in other locations
2. A history of long-term use of sedative and analgesic drugs
3. Uncontrollable hypertension
4. Hyperglycemia
5. Severe liver and kidney dysfunction
6. Other contraindications for surgery

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Blood pressure level measured using the cuff three times a day, three days, one week and one month after surgery<br>2. Pain measured using a Visual Analog Scale (VAS) on the day, three days and one week after surgery<br>3. Body function and cognition measured using the unified standard rating scale after the operation<br>4. Rehabilitation will be measured by Specialists to establish a unified standard of physical examination to judge the rehabilitation of patients after the operation<br>5. Surgical complications, incidence of target organ injury (stroke, acute coronary syndrome, kidney injury), average length of stay, ICU transfer rate, and postoperative outcomes measured using data collected in patient medical records on the day, three days, one week, and one month after surgery<br>

Secondary Outcome Measures

Name	Time	Method
1. Perioperative stress indexes (blood glucose and cortisol) and inflammatory indexes (IL-6, TNF-a and C-reactive protein) measured using standard tests in venous blood samples before surgery, on the day after surgery, and on the second and third days after surgery, respectively, at 8 pm<br>2. Target organ function indicators (myocardial enzyme profile, urea nitrogen, creatinine, NSE and S100ß) measured using standard tests in venous blood samples at 8 pm on the first day, three days and one week after surgery<br>