Effects of a 12-week multi-strain probiotic intervention on cognitive symptoms, kynurenine biomarkers and the gut microbiota in multiple sclerosis (MS); a pilot quasi-randomised, double-blind, placebo-controlled trial.

niversity of Tasmania0 个研究点目标入组 28 人开始时间: 2022年4月28日最近更新: 2023年4月24日

试验速览

暂无简介。

•(1)A diagnosis of clinically definite Relapsing Remitting MS, as defined by the McDonald criteria (as diagnosed by their treating neurologist).
•(2)Aged between 18 and 70 years
•(3)Able to speak and read English
•(4)Not currently taking probiotic supplements
•(5)Have not taken regular probiotic supplements within the previous 3 months or if so, willing to undertake an 8-week washout

•(1)A diagnosis of a psychotic, bipolar or related disorder
•(2)A history of brain injury or other neurological illness (e.g., stroke, epilepsy)
•(3)A significant history of alcohol or illicit drug abuse
•(4)MS disease relapse (symptom flare-up) within 2 weeks of assessment
•(5)Unable to speak and read English
•(6)Uncorrected visual difficulties such that the participant is unable to read and undertake tasks
•(7)Pregnant
•(8)Currently taking or have taken regular probiotic supplements within the previous 3 months and unwilling to undertake an 8-week washout
•(9)Active infection treated by antibiotic therapy at the time of screening
•(10)Risky alcohol consumption in the previous 3 months, as defined by NHMRC guideline 1 (no more than 10 standard drinks a week and no more than 4 standard drinks on any one day).

发起方

niversity of Tasmania