Short-term effects of apple consumption on endothelial function in volunteers at risk for cardiovascular disease

Edith Cowan University0 个研究点目标入组 30 人开始时间: 2018年2月21日最近更新: 2019年7月15日

适应症

试验速览

暂无简介。

•Men and women will be aged between 18 and 75 years
•Volunteers are included in the study if they have at least one of the following: elevated blood pressure (120 mmHg< systolic BP <150 mmHg), moderately elevated blood sugar levels (5.6 mmol/L< glucose <6.5 mmol/L), raised fasting cholesterol (5 mmol/L < total cholesterol <8 mmol/L) or central obesity (measured by waist circumference; men >94 cm; women >80 cm).

•Body mass index <18 or >40 kg/m2
•Systolic blood pressure greater than or equal to 150 mmHg
•Diastolic BP greater than or equal to 100 mmHg
•Diagnosed diabetes
•Non-diabetic individuals with fasting plasma glucose concentrations greater than or equal to 6.5 mmol/L
•Current or recent (<12 months) smoking
•History of cardiovascular or peripheral vascular disease
•Use of blood pressure lowering or cholesterol lowering medication
•Psychiatric illness or other major illnesses such as cancer
•Alcohol intake >210 g per week for women and >280 g per week for men
•Current or recent (within previous 6 months) significant weight loss or gain (>6% of body weight) or actively trying to lose weight
•Women who were lactating, pregnant or wishing to become pregnant during the study.
•Inability to attend clinic/office visits
•Use of antibiotics (within previous 2 months)
•current or recent (<6 months) smoking
•Inability or unwillingness to follow the study protocol
•Systolic blood pressure less than or equal to 100 mmHg
•Diastolic BP less than or equal to50 mmHg

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