Background: Isometric Handgrip (IHG) is a Classic Sympatho- Excitatory Stimulus Often Used in Autonomic Testing. Aims: The Aims of This Study Were to Evaluate the Acute Cardiovascular Response and Recovery Following Isometric Handgrip (HG) Exercise-induced Fatigue on Healthy Adults. Secondary, to e

Completed

• Conditions: Isometric Exercise

• Registration Number: NCT07051837
• Lead Sponsor: October 6 University

Brief Summary

: Isometric handgrip (IHG) is a classic sympatho- excitatory stimulus often used in autonomic testing.

Aims: The aims of this study were to evaluate the acute cardiovascular response and recovery following isometric handgrip (HG) exercise-induced fatigue on healthy adults. Secondary, to examine correlations between isometric handgrip strength and both systolic (SBP) and diastolic (DPB) blood pressure' Methods: Study was a repeated measure single group design. Thirty-five healthy volunteers, 20 females and 15 males, age (36.16 + 6.11years) were enrolled in the study. Study was at out Clinic of October 6 University. Demographic data were collected at beginning of session. Subjects were then assessed for baseline (BL) blood pressure (BP). Maximal isometric voluntary contraction (MIVC) for each subject was the average of two-5 seconds MIVCs of dominant hand using a hand-held dynamometer separated by 1 minute of rest. Subjects were allowed 5 minutes rest, then performed fatigue protocol (FP) using the hand-held dynamometer with their dominant hand at 50% MIVC for 3 minutes as a One minute of rest was given following FP then subjects were reassessed for BP and MIVC of dominant hand respectively (Immediate reassessment). Further, BP was reassessed for 3 times at 5 minutes interval between measures.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-02
• Primary Completion: 2025-04-03
• Study Completion: 2025-05-06
• Study First Submitted: 2025-06-24
• Status Verified: 2025-07
• Study First Submitted QC: 2025-07-02
• Last Update Submitted: 2025-07-02
• Study First Posted: 2025-07-04
• Last Update Posted: 2025-07-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Participants should fulfil the criteria set for age and BMI ranges. All participants should be medically stable and normotensive. They should not have any physical limitations that prevent performance of IHG exercises.

Exclusion Criteria

• Patients will be excluded from the study if they are smokers, under any medications, diabetics, diagnosed with cardiovascular diseases. Also if they have orthopaedic limitations or mental problems that affect the participation and the result of the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to evaluate the acute cardiovascular response and recovery following isometric handgrip exercise-induced fatigue on healthy adults. and to examine correlations between isometric handgrip strength and both systolic and diastolic blood pressure	from April 2024toMay 2025	Maximal isometric voluntary contraction (MIVC) for each subject was the average of two-5 seconds MIVCs of dominant hand using a hand-held dynamometer separated by 1 minute of rest. Subjects were allowed 5 minutes rest, then performed fatigue protocol (FP) using the hand-held dynamometer with their dominant hand at 50% MIVC for 3 minutes as a One minute of rest was given following FP then subjects were reassessed for BP and MIVC of dominant hand respectively (Immediate reassessment). Further, BP was reassessed for 3 times at 5 minutes interval between measures

Trial Locations

Locations (1)

Amira Mohamed Afify; 🇪🇬 Giza, Egypt