Midkine and ACE-Ang II Induced Endothelial Injury in Sepsis

Completed

• Conditions: Sepsis

• Registration Number: NCT02605681
• Lead Sponsor: Southeast University, China

Brief Summary

Plasma midkine has reported to be elevated in infection and a regulator of angiotensin-converting enzyme (ACE). We aimed to investigate the plasma midkine in septic patients and its association with 28-day mortality and organ function, and also with plasma ACE and angiotensin II.

Detailed Description

This study showed that Ang II induced endothelial injury in sepsis patients. Midkine has been shown to regulate the renin-angiotensin system and acts in the upstream signaling pathway of angiotensin (ANG) II. The investigators want to access the relationship between midkine level and ACE-Ang II induced endothelial injury in sepsis

Study Timeline

• Study First Submitted: 2015-11-12
• Study First Submitted QC: 2015-11-13
• Study First Posted: 2015-11-16
• Study Start: 2016-11-01
• Primary Completion: 2018-03-31
• Study Completion: 2018-06-15
• Status Verified: 2018-12
• Last Update Submitted: 2018-12-11
• Last Update Posted: 2018-12-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
28-day mortality	up to 28 days	All the patients were followed-up to 28 days and all-cause mortality was recorded.

Trial Locations

Locations (1)

Department of Critical Care Medicine; 🇨🇳 Nanjing, Jiangsu, China