Imipenem in Critically Ill Patients
- Registration Number
- NCT03776305
- Lead Sponsor
- Prince of Songkla University
- Brief Summary
Extracorporeal membrane oxygenation (ECMO) has become increasingly used for lifesaving respiratory and/or cardiac failure support in critically ill patients, including those with life-threatening severe infections. This cardiopulmonary bypass device has been shown to enhance the profound pathophysiological changes in this patient population, resulting in an alteration of the pharmacokinetics (PK) of antimicrobial agents. The aim of this study was to determine the effect of ECMO on the PK of imipenem in critically ill patients supported by this cardiopulmonary bypass device.
Methods The study was conducted in critically ill patients with respiratory and/or cardiac failure and suspected severe nosocomial infections who were supported by ECMO. All patients received a 1-h infusion of 0.5 g of imipenem every 6 h and imipenem PK studies were carried out on the fourth dose of drug administration.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 12
- Patient age >18 year
- Patients who diagnosed as severe sepsis
- Admitted into the ICU
- Supported with ECMO
- Patients who pregnant
- Patients who have documented hypersensitivity to carbapenem
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Imipenem ECMO Imipenem 1-h infusion of 0.5 g of imipenem, q6h
- Primary Outcome Measures
Name Time Method Concentration of imipenem in plasma 6 hour after the imipenem dose Individual concentration of imipenem in plasma
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine, Prince of Songkla University
🇹ðŸ‡Hat Yai, Songkla, Thailand