The Effect of Two Doses of Coenzyme Q10 on Seminal Fluid Parameters and Antioxidant Status: A Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 65
- 试验地点
- 2
- 主要终点
- Sperm motility in semen (WHO 2010 guidelines)
研究概览
简要总结
The study was conducted to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men.
详细描述
The aim of this study was to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
盲法说明
Open Label
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •History of infertility of at least 12 months despite regular unprotected intercourse.
- •Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (<15 million/ml), progressive motility (<32%), total motility (<40%) and morphology (<30% WHO criteria) as defined by WHO manual for semen analysis 2010
排除标准
- •Azoospermia,
- •Varicocele,
- •Genital tract infection,
- •Cryptorchidism,
- •Testicular trauma or scrotal surgery,
- •Endocrine disorder,
- •Systemic illness,
- •The presence of female factor
研究组 & 干预措施
Coenzyme Q10 200
Coenzyme Q10 200mg/day for 3 months
干预措施: Coenzyme Q10 200 (Dietary Supplement)
Coenzyme Q10 400
Coenzyme Q10 400mg/day for 3 months
干预措施: Coenzyme Q10 400 (Dietary Supplement)
结局指标
主要结局
Sperm motility in semen (WHO 2010 guidelines)
时间窗: 3 months
Sperm motility (%)
Sperm morphology in semen (WHO 2010 guidelines)
时间窗: 3 months
Normal sperm morphology (%)
Semen volume (WHO 2010 guidelines)
时间窗: 3 months
Semen volume in ml
Sperm concentration in semen (WHO 2010 guidelines)
时间窗: 3 months
Sperm concentration in million/ml
Seminal plasma TAC
时间窗: 3 months
Seminal plasma total antioxidant capacity in mmol/ml
Seminal plasma SOD
时间窗: 3 months
Superoxide dismutase in U/ml
Seminal plasma CAT
时间窗: 3 months
Seminal plasma catalase in U/ml
次要结局
未报告次要终点
研究者
Dr. Ahmed T Alahmar
Principal Investigator
University of Sumer