ISRCTN11342830
Completed
未知
The effect of canagliflozin 300 mg, in subjects without diabetes after bariatric surgery, on glucose homeostasis (the CONTROL study): a proof-of-concept, randomised, open-label, two-period crossover study
niversity of Leicester0 sites36 target enrollmentJuly 24, 2020
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Hypoglycaemia after eating due to weight-loss surgery
- Sponsor
- niversity of Leicester
- Enrollment
- 36
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Age \=18 years old but less than 75 years old
- •2\. \=1 year after gastric bypass (RYGB) or sleeve gastrectomy (SG)
- •3\. Able to understand written and spoken English
- •4\. Able to give informed consent
Exclusion Criteria
- •1\. Use of any glucose\-lowering medication (including insulin)
- •2\. Adrenal insufficiency and/or substitution with glucocorticoids
- •3\. ALT \> 1\.5 times the upper normal limit
- •4\. Moderate to severe renal impairment (eGFR\< \= 60 ml/min/1\.73m2\)
- •5\. Individuals on loop diuretics
- •6\. Participants with established diagnosis of postural hypotension by their GP
- •7\. Recent active infection (over the last 10 days)
- •8\. Current use of steroids
- •9\. Other bariatric procedure except RYGB/SG
- •10\. Previous revisional bariatric surgery
Outcomes
Primary Outcomes
Not specified
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