To Study Variations in End Tidal Carbon Dioxide (EtCO2) Values in Patients Undergoing Endoscopic Procedures Under Total Intravenous Anaesthesia (TIVA): An Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 126
- 试验地点
- 1
- 主要终点
- To assess variations in End tidal carbon dioxide (EtCO2) values during endoscopic procedures
研究概览
简要总结
Endoscopic procedures like ERCP and colonoscopy are common diagnostic and therapeutic interventions used to visualize and treat conditions within the gastrointestinal tract. These procedures involve the insertion of a flexible tube equipped with a camera through the mouth (ERCP) or rectum (colonoscopy), allowing physicians to examine and address various gastrointestinal issues. However patient needs to be under adequate depth of anaesthesia to allow smooth passage of endoscope.
Total intravenous anaesthesia(TIVA) with Fentanyl,propofol and Dexmeditidone, often used for endoscopic procedures, offers several advantages, such as precise control of drug administration, rapid onset and offset of anaesthesia, and a reduced risk of postoperative complications. Monitoring of patients during such procedures is of utmost importance to ensure their safety and well-being.
During endoscopic procedures, the medications used can have significant effects on the patient’s respiratory function. Capnography is a non-invasive method of measuring end-tidal carbon dioxide (EtCO2) and for real-time respiratory monitoring. Changes in EtCO2 levels can signal alterations in respiratory rate, tidal volume, and overall respiratory function.
In the present study we aim to study variations in End tidal carbon dioxide(EtCO2) values in endoscopic procedure like ERCP and colonoscopy which are done under total intravenous anaesthesia(TIVA). All patients who are undergoing endoscopic procedures like ERCP and colonoscopy will be considered for this study. Standard monitors like Electrocardiography, Blood pressure(BP) monitor will be attached to patient. A nasal canula with an sampling port will be connected to bedside monitor that displays a time based capnogram and EtCO2values (in mm Hg), respiratory rate.
Incidence of respiratory depression, severe hypoxia, endoscopist satisfaction and interventions needed during endoscopic procedures done under total intravenous anaesthesia (TIVA) shall be looked for.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Adult patients age between 18– 65 years Both gender ASA physical status I II and III Patient undergoing endoscopic procedures (eg ERCP colonoscopy) under TIVA.
排除标准
- •Patients who refuse to give consent to participate in study Patients with history of respiratory disorders with pre op EtCO2 more than 40 or SpO2 less than 90% Patients with trauma and bleeding on face where it is difficult to insert prongs and monitor EtCO2 Patients with Systolic blood pressure less than 90 mmHg heart rate less than 50 beats per min prior to procedure Pre operatively presence of underlying disease requiring oxygen Pregnant women Patients who are intubated prior to procedure.
结局指标
主要结局
To assess variations in End tidal carbon dioxide (EtCO2) values during endoscopic procedures
时间窗: baseline, at the time of induction, during procedure every 10 minutes upto first 30 minutes, then every 15 minutes upto 1 hour, then every 30 minutes upto 2 hours, at the end of procedure and in recovery every 10 minutes for 30 minutes post procedure
次要结局
- To determine incidence of respiratory depression, severe hypoxia,patient and endoscopist satisfaction and interventions needed(baseline, at the time of induction, during procedure every 10 minutes upto first 30 minutes, then every 15 minutes upto 1 hour, then every 30 minutes upto 2 hours, at the end of procedure and in recovery every 10 minutes for 30 minutes post procedure)
研究者
Dr Prerana Nirav Shah
Seth Gordhandas Sunderdas Medical College King Edward Memorial Hospital