BReath Analysis in intensive care: proof of concept for non-invasive diagnosis of Ventilator associated pneumonia

R&D University Hospital South Manchester0 sites120 target enrollmentJuly 2, 2015

Overview

Registry

who.int

Start Date

July 2, 2015

End Date

March 1, 2017

Last Updated

5 years ago

Study Type

Observational

Sex

All

Sponsor

R&D University Hospital South Manchester

•Inclusion criteria
•1\. 18 years and older
•2\. Intubated and mechanically ventilated for \>48 hours
•3\. Suspected for ventilator associated pneumonia (VAP)
•Definition of suspected VAP
•Criteria for clinically suspected VAP are fulfilled if a patient has been intubated and mechanically ventilated for at least 48 hours and has new or worsening alveolar infiltrates on chest X\-ray and has two or more from
•1\. Temperature \>38°C or \<35ºC
•2\. White cell count \>11x109 or \<4x109 per litre of blood
•3\. Purulent tracheal secretions

•1\. Patients receiving end of life care
•2\. Patients where there is clinical suspicion of highly infectious disease (patients in strict isolation such as Middle East Respiratory Syndrome, Ebola or resistant tuberculosis)
•3\. Patients showing features considered to predict poor tolerance of BAL:
•3\.1\. PaO2 \<8 kPa on FiO2 \>0\.7
•3\.2\. Positive end\-expiratory pressure \>15 cmH2O
•3\.3\. Peak airway pressure \>35 cmH2O
•3\.4\. Heart rate \>140 bpm
•3\.5\. Mean arterial pressure \<65 mmHg
•3\.6\. Bleeding diathesis (including platelet count \<20 x 109 p/L of blood or international normalised ratio (INR) \>3\)
•3\.7\. Poorly controlled intracranial pressure (\>20mmHg)