A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Morphine consumption (mg)
研究概览
简要总结
The purpose of this study is to determine whether dexmedetomidine added to morphine is effective in the treatment of chronic cancer pain.
详细描述
We conduct the study in Cukurova University Faculty of Medicine Research Hospital after obtaining ethics committee approval and patient's informed consent. Patients with cancer pain are allocated into two group to receive Patient Controlled Analgesia with morphine or morphine plus dexmedetomidine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with chronic cancer pain
- •between 20-80 years old age
排除标准
- •the presence of severe systemic disease(cardiac, pulmonary, hepatic or renal)
- •psychiatric or neurologic disease
- •unable to communicate verbally
- •nausea and vomiting
- •patient's refusal
研究组 & 干预措施
Control
Morphine, 0.02 mg/kg PCA bolus dose with 10 minutes lock-out interval
干预措施: Morphine (Drug)
Morphine plus dexmedetomidine
Morphine 0.02 mg/kg plus dexmedetomidine 0.1 microgram/kg PCA bolus dose with 10 minutes lock-out interval
干预措施: Morphine plus dexmedetomidine (Drug)
结局指标
主要结局
Morphine consumption (mg)
时间窗: 24 hours
cumulative morphine consumption for 24 hours
次要结局
- Pain score(24 hours)
研究者
Ersel GULEC
Ersel Gulec
Cukurova University