Effects of Probiotic and HIIT in Obese Women

Not Applicable

Completed

• Conditions: Anthropometry; Cardiorespiratory Fitness; Metabolism

• Registration Number: NCT06285578
• Lead Sponsor: University of Taipei

Brief Summary

The aim of this study is to investigate whether there are the additive effects when implementing both high-intensity interval training (HIIT) and probiotics simultaneously on improving cardiorespiratory endurance and metabolism in middle-aged women.

Detailed Description

High-intensity interval training (HIIT) is a time-efficiency exercise mode that has been shown to reduce body fat, fasting blood insulin levels, arterial stiffness, and aerobic capacity, helping to prevent and improve chronic diseases. Probiotics, on the other hand, have been found to have similar effects, including improving insulin sensitivity and endurance exercise performance, as well as reducing body fat. However, the additive effects of HIIT combined with probiotic supplements are unclear. In addition, on average, the life expectancy of women is longer than that of men. Middle-aged women are at high-risk for obesity and metabolic-related problems that threaten their long-term health. Therefore, whether the combination of HIIT and probiotics can be utilized to enhance the wellness of middle-aged women is the objective of this study.

Study Timeline

• Study Start: 2018-10-01
• Primary Completion: 2019-01-31
• Study Completion: 2019-03-01
• Status Verified: 2024-02
• Study First Submitted: 2024-02-13
• Study First Submitted QC: 2024-02-22
• Last Update Submitted: 2024-02-22
• Study First Posted: 2024-02-29
• Last Update Posted: 2024-02-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 47

Inclusion Criteria

• Female
• Age between 35-55 years old
• Total body fat percentage greater than 30%

Exclusion Criteria

• Male
• Participants who were taking probiotics supplementation or antibiotics
• Percentage of total body fat less than 30%

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Total cholesterol (TC)	8 weeks	TC in mg/dL
Waist circumference	8 weeks	Waist circumference in centimeters
Fasting blood glucose (FBG)	8 weeks	FBG in mg/dL
Body fat percentage	8 weeks	Body fat percentage (%) is measured with Dual-energy X-ray absorptiometry (DEXA)
Hip circumference	8 weeks	Hip circumference in centimeters
Maximum oxygen uptake (VO2max)	8 weeks	VO2max in ml/min/kg
Time to exhaustion (TTE)	8 weeks	TTE in seconds
Running economy (RE)	8 weeks	RE in ml/kg/km
Triglyceride (TG)	8 weeks	TG in mg/dL
High-density lipoprotein cholesterol (HDL-C)	8 weeks	HDL-C in mg/dL
Low-density lipoprotein cholesterol (LDL-C)	8 weeks	LDL-C in mg/dL
Height	8 weeks	Height in centimeters
Body mass index (BMI)	8 weeks	Calculated by: weight (kg)/ height (m\^2)
Body weight	8 weeks	Weight in kilograms

Secondary Outcome Measures

Name	Time	Method
Muscle mass	8 weeks	Muscle mass in kilograms is measured with DEXA
Fat mass	8 weeks	Fat mass in kilograms is measured with DEXA
Bone mineral density (BMD)	8 weeks	BMD in g/cm\^2 is measured with DEXA
Caloric intake	8 weeks	Caloric intake in kcal/day

Trial Locations

Locations (1)

University of Taipei; 🇨🇳 Taipei, Taiwan