Immune Dysregulation in Hepatitis C Patients With or Without Arthritis

• Conditions: Hepatitis C Patients

• Registration Number: NCT01195987
• Lead Sponsor: The Center for Rheumatic Disease, Allergy, & Immunology

Brief Summary

The purpose of this study is to study the role of the Immune System in causing arthritis in patients with Hepatitis C.

Detailed Description

Patients will provide one blood sample after qualifying for the study, and signing consent. The patients will have a skin test TB, Candida, and Trichophyton placed and will read the results themselves and mail back the card with the measurements to be recorded. Labs will test for ESR, CBC, CRP, antiCCP, Cryoglobulins, RF, CH50, C3, C4, Flow cytometry, and would have already been tested for HIV and Hepatitis C.

Study Timeline

• Study Start: 2010-06
• Status Verified: 2010-09
• Study First Submitted: 2010-09-03
• Study First Submitted QC: 2010-09-07
• Last Update Submitted: 2010-09-07
• Study First Posted: 2010-09-08
• Last Update Posted: 2010-09-08
• Primary Completion: 2011-08
• Study Completion: 2011-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• All adults 18 or older, 20 will have hep C positive with a viral load withen 6 mo. of enrollment.
• Either interferon or antiviral naive or those who failed interferon or antiviral therapy more than 6 mo. prior to enrollment.
• 10 normal healthy controls- Hep C neg and without osteoarthritis (OA).

Exclusion Criteria

• HIV patients
• Those with concomitant alcoholic liver disease
• Patients with Rheumatoid Arthritis (RA) or other autoimmune disorders.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Center for Rheumatic Disease, Allergy & Immunology; 🇺🇸 Kansas City, Missouri, United States