Changes in Macular Pigment Optical Density After Full-thickness Macular Hole Closure Using Inverted Flap Technique
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- MPOD After Full-thickness Macular Hole Closure (FTMH)
Study Overview
Brief Summary
The notable increase in MPOD following successful surgery suggests its potential role as a valuable adjunctive biomarker associated with a good visual prognosis following this type of macular hole surgical interventions.
Detailed Description
Full-thickness macular hole (FTMH) is a debilitating retinal disorder, particularly in its advanced forms, necessitating surgical intervention for vision restoration. This study showes the successful closure of a large FTMH using the inverted flap technique, highlighting the essential role of multimodal imaging, and particularly of macular pigment optical density (MPOD) assessment, in preoperative and postoperative evaluation.
Surgery was performed by an expert vitreoretinal surgeon, resulting in significant postoperative improvements in visual acuity and retinal architecture. Multimodal imaging, including MPOD assessment, played a pivotal role in preoperative evaluation and postoperative monitoring.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •age older than 60 years
- •diagnosis of FTHM
- •absence of other ocular diseases, responsible for macular edema (retinal vein occlusion, diabetic retinopathy, age-related macular degeneration
Exclusion Criteria
- •No diagnosis of pseudophakic cystoid macular oedema
- •previous treatment for pseudophakic cystoid macular oedema
- •presence of other ocular diseases, responsible for macular edema (retinal vein occlusion, diabetic retinopathy, age-related macular degeneration)
Outcomes
Primary Outcomes
MPOD After Full-thickness Macular Hole Closure (FTMH)
Time Frame: 6 months
The parameters analyzed by OCT and MPOD six months after surgery are: OCT MPOD visual acuity
MPOD and Macula hole: before and after surgery
Time Frame: six months
The parameters analyzed six months after surgery are: MPOD Visual acuity OCT
Secondary Outcomes
No secondary outcomes reported
Investigators
Ciro Costagliola
director
Federico II University