Transfer of Aneuploid or Mosaic Embryos Following Preimplantation Genetic Testing
Overview
- Phase
- Not Applicable
- Intervention
- Non-euploid embryo transfer
- Conditions
- Not specified
- Sponsor
- Stanford University
- Enrollment
- 300
- Locations
- 2
- Primary Endpoint
- Pregnancy Rate
- Status
- Recruiting
- Last Updated
- 8 days ago
Overview
Brief Summary
To determine how often embryos reported to be abnormal by preimplantation genetic testing result in liveborn infants. To evaluate whether the pregnancies that result from these embryos are higher risk for complications and whether the resulting babies have higher risk for health or developmental issues in the first five years after birth.
Detailed Description
Genetic testing modality and results will be recorded Pregnancy per transfer will be recorded Patients in the study agree to provide medical records of their pregnancy. Any genetic testing or fetal testing will be carefully reviewed and recorded by the study team. For patients with live births, pediatric records will be collected for up to 5 years. As well as surveys for developmental milestones. There is no financial compensation for study participants
Investigators
Ruth Bunker Lathi
Professor
Stanford University
Eligibility Criteria
Inclusion Criteria
- •Available aneuploid or mosaic embryos
- •No other acceptable embryos available
- •Willing to travel to Stanford for treatment
- •English language fluency
Exclusion Criteria
- •Use of international donor eggs or sperm not tested according to FDA guidelines.
- •Living outside the United States
- •Embryos with Triploidy are not eligible for transfer in this protocol
Arms & Interventions
Non-euploid Transfer
Patients desiring pregnancy who have no acceptable euploid embryos available for transfer who chose to undergo embryo transfer of a non-euploid embryo (either aneuploid or mosaic).
Intervention: Non-euploid embryo transfer
Euploid Transfer
Patients desiring pregnancy who are undergoing euploid embryo transfer
Intervention: Euploid Transfer
Outcomes
Primary Outcomes
Pregnancy Rate
Time Frame: 3 years
Number participants who undergo embryo transfers that lead to a positive pregnancy test
Secondary Outcomes
- Live birth rate(4 years)
- Obstetric complications(4 years)
- Pediatric Development(7 years 3 months)