Transfer of Aneuploid or Mosaic Embryos Following Preimplantation Genetic Testing
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- Pregnancy Rate
研究概览
简要总结
To determine how often embryos reported to be abnormal by preimplantation genetic testing result in liveborn infants. To evaluate whether the pregnancies that result from these embryos are higher risk for complications and whether the resulting babies have higher risk for health or developmental issues in the first five years after birth.
详细描述
Genetic testing modality and results will be recorded
Pregnancy per transfer will be recorded
Patients in the study agree to provide medical records of their pregnancy.
Any genetic testing or fetal testing will be carefully reviewed and recorded by the study team.
For patients with live births, pediatric records will be collected for up to 5 years.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Available aneuploid or mosaic embryos
- •No other acceptable embryos available
- •Willing to travel to Stanford for treatment
- •English language fluency
排除标准
- •Use of international donor eggs or sperm not tested according to FDA guidelines.
- •Living outside the United States
- •Embryos with Triploidy are not eligible for transfer in this protocol
研究组 & 干预措施
Non-euploid Transfer
Patients desiring pregnancy who have no acceptable euploid embryos available for transfer who chose to undergo embryo transfer of a non-euploid embryo (either aneuploid or mosaic).
干预措施: Non-euploid embryo transfer (Other)
Euploid Transfer
Patients desiring pregnancy who are undergoing euploid embryo transfer
干预措施: Euploid Transfer (Other)
结局指标
主要结局
Pregnancy Rate
时间窗: 3 years
Number participants who undergo embryo transfers that lead to a positive pregnancy test
次要结局
- Live birth rate(4 years)
- Obstetric complications(4 years)
- Pediatric Development(7 years 3 months)
研究者
Ruth Bunker Lathi
Professor
Stanford University