Study on the Correlation Between Fat Soluble Vitamins and Non-alcoholic Fatty Liver Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 4,000
- 试验地点
- 1
- 主要终点
- serum vitamin A
研究概览
简要总结
Excessive or insufficient levels of vitamins in the body can affect health. With the prevalence of obesity and MetS, NAFLD has become the leading cause of chronic liver disease and abnormal liver biochemical indicators in health examinations in China. The current research results on serum vitamin A, D, and E levels in NAFLD patients are controversial. Therefore, this study mainly explores the correlation between serum FSV levels and NAFLD, providing reference for nutrition and clinical management of NAFLD patients.
详细描述
This is a single center cross-sectional study. In this study, 4000 eligible patients will be recruited and demographic information and clinical data of all study subjects will be collected. According to the results of abdominal ultrasound, the patients were divided into NAFLD group and non NAFLD group. The levels of fat soluble vitamins in the two groups were compared to explore the correlation between different concentrations of fat soluble vitamin levels and the risk of NAFLD.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 18 years old, both male and female;
- •Voluntarily participate in this study and sign an informed consent form;
- •Diagnosed NAFLD through abdominal ultrasound;
排除标准
- •Acute and chronic infections, severe cardiovascular and cerebrovascular diseases, respiratory system diseases, urinary system diseases, rheumatic diseases, tumors, and pituitary dysfunction; Or have hepatitis B, hepatitis C virus, or acquired immunodeficiency syndrome;
- •Surgery was performed within 6 months, and blood donation, transfusion, or significant blood loss occurred within 4 months;
- •Have taken vitamin supplements within 2 weeks;
- •Women are in pregnancy, lactation, or within one year after childbirth;
- •Alcohol abuse (alcohol intake ≥ 140 g/week for males and ≥ 70 g/week for females)
- •The serum creatinine (SCr) exceeds twice the following abnormal values, with the standard of abnormal values being: male (20-59 years old)>97 μ mol/L, male (60-79 years old)>111 μ mol/L; Female (20-59 years old)>73 μ mol/L, female (60-79 years old)>81 μ mol/L.
结局指标
主要结局
serum vitamin A
时间窗: Day 1
non-alcoholic fatty liver disease prevanlence
时间窗: Day 1
serum vitamin k
时间窗: Day 1
serum vitamin D
时间窗: Day 1
serum vitamin E
时间窗: Day 1
次要结局
未报告次要终点
研究者
Liu Zhong
Clinical Professor
First Affiliated Hospital of Zhejiang University