Human skin barrier recovery

Recruiting

• Conditions: atopic ezema; skin barrier impairment; 10014982

• Registration Number: NL-OMON43983
• Lead Sponsor: niversiteit Leiden

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 8

Inclusion Criteria

- age between 18 and 40.
- Caucasian
- AE is present for * 2 years
- TEWL values before the start of the study are * 15 g/m2/h on non-lesional skin

Exclusion Criteria

- Abundant hear, tattoos, or lesions on the underarm
- Chronically inflammatory (skin)disease, except AE;
- Dermatological disorders or a history of dermatological disorders (not AE);
- History of drug abuse;
- Pregnancy;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters and endpoints are: the physical properties of the SC<br /><br>lipid matrix after barrier recovery. These are assessed as, the lipid<br /><br>composition (measured by liquid chromatography/mass spectrometry (LC-MS)) and<br /><br>lipid organization (measured by attenuate total reflectance Fourier transform<br /><br>infrared spectrometry (ATR FTIR)). Another pirmary study parameter is the<br /><br>barrier function of the skin. The transepidermal water loss will be used to<br /><br>determine this. A third primary parameter is the disease severity, for which<br /><br>(local)SCORAD and EASI will be used.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>