Effects of Low Density Lipoprotein Apheresis on Oxidative Stress and Endothelial/Vascular Smooth Muscle Cell Function in Patients with Peripheral Arterial Disease and End-stage Renal Disease
Not Applicable
- Conditions
- peripheral artery disease, end-stage renal disease on hemodialysis
- Registration Number
- JPRN-UMIN000000652
- Lead Sponsor
- Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
1. Poor controlled diabetics, 2. Poor controlled hypertensives, 3. Moderate to severe liver dysfunction, 4. Judged as unsuitable from other reasons.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Clinical papameters 1) Signs & symptoms (pain at rest, intermittent claudication, walking distance) 2) Blood biochemistry (serum lipid including total cholesterol and LDL, coaglatory factors including fibrinogen, CRP, oxidised LDL, MDA-LDL, AGE, VEGF, HGF). 3) ABI/baPWV 2. Vascular cell functions 1) Human vascular endothelial cells (commercially available) (ecNOS expression, proliferative activity, tube formation activity) 2) Human vascular smooth muscle cells (commercially available)(expressions of AT1 receptor and its interacting molecule ATRAP, growth factors, extracellular matrix, proliferation activity).
- Secondary Outcome Measures
Name Time Method