The dynamics of the ACTH and cortisol response to CRH stimulation during critical illness: a randomized, double-blind, placebo-controlled crossover study

Katholieke Universiteit Leuven (Belgium)0 个研究点目标入组 60 人开始时间: 2016年7月7日最近更新: 2022年9月5日

适应症

试验速览

•For patients:
•1. Critically ill patients at the surgical or medical intensive care units, with ongoing intensive care dependency, a stable condition for at least 48h, and an expected stay in ICU for at least 48h
•2. Age =18 years
•For healthy volunteers:
•1. Age-, gender- and BMI-matched to the included patients

•For patients:
•1. Predisposing factors of adrenal insufficiency
•1.1. Cerebral disease with intracranial hypertension threatening the neuroendocrine system
•1.2. Pituitary disorders including (pan)hypopituitarism
•1.3. Known adrenal disease (Cushing’s syndrome or Addison’s disease)
•1.4. Chronic treatment with glucocorticoids, other steroids or anti-steroid chemotherapy within the last 3 months
•1.5. IV administration of glucocorticoids within the last 72 hours
•1.6. Use of etomidate within the last 72 hours
•1.7. Use of azoles within the last 7 days
•1.8. Other drugs predisposing to adrenal insufficiency: phenytoin, rifampicin, glitazones, imipramin, phenothiazine, phenobarbital
•2. Patients known to be pregnant or nursing
•3. No arterial line or central venous catheter in place
•4. Ethical restrictions
•4.1. Moribund
•4.2. Declined participation
•For healthy volunteers:
•1. Recent history of treatment with HPA-axis interfering drugs

发起方

Katholieke Universiteit Leuven (Belgium)