Efficacy of Ozone Gel, Doxycycline Saturated Chitosan Dressing Versus Alveogyl

Not Applicable

Completed

• Conditions: Osteitis; Dry Socket
• Interventions: Drug: Ozone gel; Drug: doxycycline hyclate saturated chitosan dressing

• Registration Number: NCT05875506
• Lead Sponsor: Minia University

Brief Summary

Efficacy of ozone gel, doxycycline saturated chitosan dressing versus Alveogyl in pain alleviation and healing of alveolar osteitis in diabetic patients

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-05
• Study Start: 2023-05-01
• Study First Submitted: 2023-05-16
• Study First Submitted QC: 2023-05-16
• Study First Posted: 2023-05-25
• Primary Completion: 2023-08-01
• Study Completion: 2023-09-01
• Last Update Submitted: 2025-01-02
• Last Update Posted: 2025-01-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients over 20 years and under 60 years of age
• DM controlled by medication, presented to outpatient clinic with signs and symptoms of dry socket
• Only participant that are willing to control and record blood glucose level throughout the study period

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Exclusion Criteria

• Patients with any significant medical condition (besides DM)
• Alcoholic individuals
• Patients on drugs that affect the central nervous systems
• Patients who reported the use of drugs that might interfere with pain sensitivity
• Pregnant and lactating women
• Hypersensitivity to local anesthetics

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Alveogyl paste	Ozone gel	Alveogyl paste ( Septodont, inc, france)
Ozone gel	Ozone gel	(Ozene; Premier Research Labs, lp, 3500-b Wadley pl, Austin, TX, USA. 78728)
doxycycline hyclate saturated chitosan dressing	doxycycline hyclate saturated chitosan dressing	doxycycline hyclate ( Atridox 10% Tolmar Inc, USA) saturated chitosan dressing (HHD) HemCon dental dressing Pro ( Tricol Biomedical, Inc. USA)
Alveogyl paste	doxycycline hyclate saturated chitosan dressing	Alveogyl paste ( Septodont, inc, france)

Primary Outcome Measures

Name	Time	Method
Pain scores will be recorded on visual analog scale (VAS)	7 days	visual analog scale (VAS) is a scale from 0 to 10. 0 indicates no pain while indicates extensive unbearable pain

Secondary Outcome Measures

Name	Time	Method
Healing score of the extraction socket	21 days	According to the amount of granulation tissue: Nil: no granulation tissue; * Granulation tissue in one quarter or less; * Granulation tissue in 2 quarters +++ Granulation tissue in 3 quarters ++++ Granulation tissue in 4 quarters

Trial Locations

Locations (1)

Faculty of Dentistry, Minia University; 🇪🇬 Minya, Egypt