Evaluation of curcumin-piperine, and Ashwagandha root powder in the management of advanced high grade osteosarcoma - OSCAT

Tata Memorial Hospital0 个研究点目标入组 24 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1.Patients (between the ages of 8 to 65 years) with histologically proven high grade osteosarcoma of the extremity and relapsed disease after primary line of treatment who are unsuitable or refuse secondary chemotherapy.
•2.Patients with advanced disease unable or unwilling to take primary conventional treatment
•3.Patients with early or non-metastatic disease who are unable or unwilling to take the standard chemotherapy.
•4.Adequate hepatic function defined by total bilirubin not more than 1.5 times the upper limit of normal (ULN) and SGOT and SGPT not more than 2.5 times the (ULN)
•5.Adequate renal function defined by the creatinine clearance greater than 50 ml/min, calculated by Cockcroft-Gault formula

•1.Patients who are suitable for second line chemotherapy and can afford it
•2.Age less than 8 years or greater than 65 years
•3.Pregnant or lactating women
•4.Patients who are unable or unwilling to provide blood samples for the drug assays.
•5.Low grade osteosarcoma
•6.Participation in any investigational drug study within 28 days prior to study treatment.

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