Near Infrared (NIR) Autofluorescence Image-guided Thyroid Surgery Can Prevent Post-thyroidectomy Hypoparathyroidism
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypoparathyroidism Postprocedural
- Sponsor
- Rigshospitalet, Denmark
- Enrollment
- 214
- Locations
- 2
- Primary Endpoint
- Postoperative hypoparathyroidism
- Last Updated
- 4 years ago
Overview
Brief Summary
The objective of this ongoing randomized controlled trial is to examine whether the use of intra-operative NIR(near infrared) camera can reduce the number of patients who experience transient or persistent hypoparathyroidism after total thyroidectomy and completion thyroidectomy, both in malignant and benign thyroid disease.
Detailed Description
Patients admitted to total thyroidectomy or completion thyroidectomy is ramdomized to: 1. Intervention: NIR optic imaging assisted identification of the parathyroid glands during thyroidectomy using parathyroid gland autofluorescence. 2. Control: Conventional thyroidectomy and parathyroid identification by the surgeon. Measurements: PTH and ionized-Ca blood samples are collected preoperatively, within 12 hours postoperatively and at 1-, 3-, 9- and 12-months follow-up. Anticipated 214 patients are included, all of which participate in 3 months follow-up. Only patients with persistent hypoparathyroidism at this point continue til maximum 12 months follow-up. An interim analysis will be conducted when inclusion of anticipated 128 patients and 3 months follow-up is reached.
Investigators
Eva Lykke
Principal investigator
Rigshospitalet, Denmark
Eligibility Criteria
Inclusion Criteria
- •Able to understand patient information and to give written informed consent
- •Patients admitted to either total thyroidectomy og completion thyroidectomy, both benign and malign.
Exclusion Criteria
- •Not able to understand patient information and to give written informed consent
- •Previous parathyroid surgery or other parathyroid decease
- •Age under 18
Outcomes
Primary Outcomes
Postoperative hypoparathyroidism
Time Frame: 24 months-follow-up
Hypoparathyroidism defined as: PTH \< 1,6 pmol/L and based on European Society of Endocrinology Clinical Guideline
Secondary Outcomes
- Parathyroidglands identified by NIR light(During surgery)
- Time(Immediately after surgery)
- Postoperative hypocalcemia(12 months follow-up)