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Clinical Trials/NCT06006195
NCT06006195
Not yet recruiting
Not Applicable

Investigating the Correlation Between Dysphagia Symptoms and Swallowing Muscle Groups by High-Resolution Pharyngeal Manometry With Impedance, Along With the Associated Nutritional Assessment

National Taiwan University Hospital0 sites50 target enrollmentAugust 28, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Swallowing Contraction Strength
Sponsor
National Taiwan University Hospital
Enrollment
50
Primary Endpoint
UES peak pressure, mmHg
Status
Not yet recruiting
Last Updated
2 years ago

Overview

Brief Summary

Investigating the correlation between the dysphagia symptoms and swallowing muscle groups by high resolution pharyngeal manometry with impedance

Detailed Description

Backgrounds: Some patients would experience dysphagia symptoms before the elective surgery. These patients usually do not have a history of head and neck surgery or cerebrovascular diseases. They are common causes of dysphagia. The anesthetics and airway manipulation can exacerbate dysphagia. However, research is limited on the specific weak muscle groups in patients with dysphagia symptoms, as well as on the existence of associated malnutrition. Aims: The Eating Assessment Tool (EAT-10) questionnaire will be used to assess dysphagia symptoms. A score of ≥4 on the EAT-10 indicates the presence of dysphagia symptoms, while a score of \<4 indicates the absence. This study aims to (1) investigate which specific muscle groups are particularly weak in patients with dysphagia symptoms (EAT-10≥4); (2) to examine whether patients with dysphagia symptoms (EAT-10≥4) have poorer nutritional status than patients without dysphagia symptoms (EAT-10\<4). Methods: This is a cross-sectional study. The investigators will recruit patients undergoing elective orthopedic surgery on the lower extremities, with the age range of 18 to 90 years. On the day of admission, patients will be examined by the EAT-10 questionnaire for dysphagia symptoms. High-resolution pharyngeal manometry with impedance will be conducted to measure the functional of swallowing muscles. Additionally, patients will be given the Mini Nutritional Assessment (MNA) questionnaire (a total score of 30 points). The higher scores indicate the better nutritional status. The albumin level will also be collected. The bioelectrical impedance analysis will be used to measure the patients' body composition, specifically skeletal muscle mass.

Registry
clinicaltrials.gov
Start Date
August 28, 2023
End Date
December 31, 2030
Last Updated
2 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

National Taiwan University Clinical Trial Center

Principal Investigator

National Taiwan University Hospital

Eligibility Criteria

Inclusion Criteria

  • age from 20 to 80 years

Exclusion Criteria

  • bleeding tendency
  • pregnancy
  • heart failure
  • chronic kidney disease

Outcomes

Primary Outcomes

UES peak pressure, mmHg

Time Frame: 10 to 15 minutes

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