SHORT-TERM EFFECTS OF BROCCOLI-DERIVED GLUCORAPHANIN ON RECOVERY FROM ECCENTRIC MUSCLE DAMAGE: A DOUBLE-BLIND RANDOMIZED CROSSOVER STUDY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 17
- 主要终点
- Peak torque, Nm/s
研究概览
简要总结
Eccentric exercise induces muscle damage and delay functional recovery. Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remains unknown. This study aims to evaluate whether short-term supplementation with broccoli-derived glucoraphanin will improve recovery from exercise-induced muscle damage. In a randomized, double-blind, placebo-controlled crossover design, fifteen participants will consume either high-glucoraphanin broccoli powder (320 μg) or placebo for one week, followed by elbow flexor eccentric exercise and continued supplementation. Strength, soreness, creatine kinase (CK), range of motion (ROM), arm girths, and ultrasound-assessed muscle and tendon morphology will be measured at baseline, immediately post-exercise, and at 48 and 96 hours post-exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •no resistance training experience in the past 6 months, no arm injuries in the past 2 years, no illnesses in the month prior to data collection, and no known allergies to broccoli or other cruciferous vegetables.
排除标准
- •incomplete participation.
研究组 & 干预措施
male volunteers aged 18-35 years
干预措施: broccoli powder consumption (Dietary Supplement)
male volunteers aged 18-35 years
干预措施: Placebo (no broccoli-derived bioactives) (Dietary Supplement)
结局指标
主要结局
Peak torque, Nm/s
时间窗: At baseline, immediately post-exercise, and at 48 hours, and at 96 hours post-exercise.
Exercise induced damage marker, isokinetic and isometric knee extension
Range of motion, degree
时间窗: At baseline, immediately post-exercise, and at 48 hours, and at 96 hours post-exercise.
Exercise induced damage marker, elbow extension and flexion
Arm girth, mm
时间窗: At baseline, immediately post-exercise, and at 48 hours, and at 96 hours post-exercise.
Exercise induced muscle damage marker, arm relaxed and fully flexed
次要结局
- Soreness, points(At baseline, immediately post-exercise, and at 48 hours, and at 96 hours post-exercise.)
- Creatine kinase, IU/L(At baseline, immediately post-exercise, and at 48 hours, and at 96 hours post-exercise.)