2023-510214-11-00招募中1 期
Individualized Systems Medicine strategy to target cancer stem cells in patients with recurrent Glioblastoma (ISM-GBM)
Oslo University Hospital HF1 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2024年10月22日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Ability to perform drug-screen and select possible treatment strategy
研究概览
简要总结
Establishment and feasability evaluation of high-throuhput drug screens of personalized tumor stem cell cultures. Success of generating an individualized treatment selection based on drug screening.
入排标准
- 年龄范围
- 18 years 至 65+ years（18-64 Years, 65+ Years）
- 接受健康志愿者
- 否
入选标准
- •Histologically verified glioblastoma
- •Must be ambulatory with an ECOG performance status 0-1
- •Must be 18 to 70 years of age.
- •Adequate bone marrow, liver and heart function
- •Signed informed consent and expected cooperation of the patients for the treatment and follow up must be obtained and documented according to ICH GCP, and national/local regulations.
排除标准
- •Patients taking part in other clinical trials which could make incusion or follow-up difficult
- •Any reason why, in the opinion of the investigator, the patient should not participate.
结局指标
主要结局
Ability to perform drug-screen and select possible treatment strategy
Ability to perform drug-screen and select possible treatment strategy
次要结局
- Tumor volume ccording to response assessment in neuro-oncology (RANO) criteria
- Adverse events induced by selected treatments
- Overall survival in treated patients
- Comparsion of drug response to individual molecular fingerprint of drug selectivity.
研究者
Einar Vik-Mo
Scientific
Oslo University Hospital HF
研究点 (1)
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