Pregabalin versus Gabapentin for the Treatment of Sciatica: A Randomised, Double-Blind, Cross-over Study.

The Townsville Hospital0 个研究点目标入组 38 人开始时间: 2013年5月17日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•18 years or older
•Diagnosis of sciatica
•First presentation to the pain clinic for intervention treatment
•Patients with continuous sciatica for over 3 months, with a corresponding physical cause proven on CT or MRI, will be considered.

•Pregnant or breastfeeding
•Prior treatment with pregabalin and or gabapentin
•Clinically relevant medical/psychological illness which might affect study participation
•Creatinine clearance <60ml/min
•Taking antiepileptics, nerve blocks muscle relaxants, anticonvulsants, mexiletine, topical analgesics, or antiviral agents.
•Patient history or laboratory results that suggested the presence of an inherited neuropathy or neuropathy attributable to other causes, such as hypothyroidism, vitamin B12 deficiency, connective tissue disease, amyloidosis, and toxic exposure
•Major organ system disease, cardiovascular autonomic neuropathy, baseline postural hypotension of more than 20 mm Hg, sedation or ataxia due to concomitant drugs or other cause, urinary symptoms attributable to benign prostatic hypertrophy in male participants, psychiatric or substance abuse disorder, hypersensitivity to any of the study drugs, or a coexisting disorder causing pain as severe as the neuropathic pain.

发起方

The Townsville Hospital