NCT00911378Unknown不适用
A Randomized Controlled Trial on Weaning by Pressure Support Reduction Versus Spontaneous Breathing Trials in a Respiratory ICU
Post Graduate Institute of Medical Education and Research, Chandigarh2 个研究点 分布在 1 个国家目标入组 130 人开始时间: 2008年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 130
- 试验地点
- 2
- 主要终点
- Rate of weaning failure
研究概览
简要总结
This study is a comparison of two most commonly used modes of weaning and the outcomes in the two groups.
详细描述
Patients ventilated for more than 24 hours are randomized into two groups - one group of patients undergo gradual reduction of pressure support and in the other, T tube trials are used for weaning. The outcomes are compared in the two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 10 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mechanically ventilated patients for more than 24 hours
- •Satisfies weaning criteria
- •RSBI < 80
- •Ratio of PaO2/FiO2 > 250
- •Arterial partial pressure of oxygen more than 60 mm Hg and carbon dioxide less than 50 mm Hg
排除标准
- •Systolic blood pressure of less than 100
- •Arterial partial pressure of oxygen less than 60 mm Hg
- •Poor sensorium
结局指标
主要结局
Rate of weaning failure
时间窗: 48 hours from extubation
次要结局
- Occurence of ventilator associated pneumonia(Until the date of discharge from hospital)
- Reintubation rates(48 hours)
- Mortality rates(Until the time of discharge from hospital)
- Duration from start of weaning to extubation(In hospital stay)
- Role of various factors that may influence the weaning outcome and hence predict the probability of successful weaning in a patient(during ICU stay)
- The influence of weaning outcome on mortality and the other complications of mechanical ventilation(during hospital stay)
研究者
研究点 (2)
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