Dose-dependent Identification of Unique Biomarkers

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Pork Consumption

• Registration Number: NCT05600348
• Lead Sponsor: San Diego State University

Brief Summary

The purpose of the research is to assess the dose-dependent impacts of the consumption of fresh pork on blood-borne metabolites (markers) following the controlled feeding of pork

Detailed Description

Eligible participants will follow 3 randomly ordered 4-week feeding periods varying only with the consumption of 0, 3 or 6 oz of pork or a 50:50 blend of chicken and beef (6, 3 and 0 oz for respective trials to ensure similar total poultry/meat intake among trials).

Study Timeline

• Study First Submitted: 2022-10-22
• Study First Submitted QC: 2022-10-26
• Study First Posted: 2022-10-31
• Study Start: 2023-01-01
• Status Verified: 2023-12
• Primary Completion: 2024-12-01
• Study Completion: 2024-12-01
• Last Update Submitted: 2025-01-06
• Last Update Posted: 2025-01-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• generally healthy (i.e., an absence of diagnosed chronic illnesses and inborn metabolic disorders)
• Age 18-65
• all races
• both sexes
• willingness to comply with the research diet requirements

Exclusion Criteria

• special dietary needs (e.g., vegetarianism, gluten-free, etc.)
• use of medication known to influence metabolism
• smoking
• substance use

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
0 oz Pork	Pork Consumption	Participants receive 0 oz pork and 6 oz 50:50 blend of chicken and beef per day
6 oz Pork	Pork Consumption	Participants receive 6 oz pork and 0 oz 50:50 blend of chicken and beef per day
3 oz Pork	Pork Consumption	Participants receive 3 oz pork and 3 oz 50:50 blend of chicken and beef per day

Primary Outcome Measures

Name	Time	Method
Metabolic biomarker discovery	4 weeks	Biomolecules detected through metabolomic profiling that will result in discovery of a metabolic signature for pork intake

Secondary Outcome Measures

Name	Time	Method
LDL-Cholesterol	4 weeks	LDL-Cholesterol
Interleukin-6	4 weeks	Interleukin-6
Total Cholesterol	4 weeks	Total Cholesterol
HDL Cholesterol	4 weeks	HDL Cholesterol
Triglycerides	4 weeks	Triglycerides
C-Reactive Protein	4 weeks	C-Reactive Protein
Fasted Glucose	4 weeks	Fasted Glucose
Insulin	4 weeks	Insulin
Blood Pressure	4 weeks	Systolic and Diastolic
Body Composition	4 weeks	Weight measured via scalre, body fat% muscle mass as measured via DEXA

Trial Locations

Locations (1)

School of Exercise and Nutritional Sciences; 🇺🇸 San Diego, California, United States