Effects of Methylphenidate and Sulpiride on Brain and Cognition: An exploratory PET, Pharmaco-fMRI Study

Donders Institute for Brain, Cognition, and Behaviour, Centre for Cognition, Radboud University Nijmegen0 sites100 target enrollmentTBD

ConditionsDopamine, cognition, working memory, striatum

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Dopamine, cognition, working memory, striatum
Sponsor: Donders Institute for Brain, Cognition, and Behaviour, Centre for Cognition, Radboud University Nijmegen
Enrollment: 100
Status: Not yet recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

No summary available.

Registry

who.int

Start Date

TBD

End Date

TBD

Last Updated

2 years ago

Study Type

Interventional

Investigators

Sponsor

Donders Institute for Brain, Cognition, and Behaviour, Centre for Cognition, Radboud University Nijmegen

Eligibility Criteria

Inclusion Criteria

•1\. Healthy volunteers;
•2\. Age 18 \- 45 years;

Exclusion Criteria

•Diagnosis (or history of) psychiatric treatment (e.g., severe depression, anorexia nervosa, severe mood disorders, mania, schizophrenia or borderline personality disorder) / Diagnosis (or history of) neurological treatment / Diagnosis (or history of) endocrine treatment / Diagnosis (or history of) neuroendocrine treatment (e.g., phechromocytoma, hyperthyroidism, Cushing’s syndrome) / (History of) melanoma / Presence of prolactin\-dependent tumors (e.g., pituitary prolactinoma or breast cancer) / (History of) requent autonomic failure (e.g., vasovagal reflex syncope) / (History of) clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, cardiovascular, metabolic, ocular or pulmonary disease/disorders / (History of) epilepsy in adulthood (i.e. no insult after 18 years of age, no current medication for epilepsy and no insult in the last five years) / (History of) drug dependence (opiate, LSD, (meth)amphetamine, cocaine, solvents, or barbiturate) or alcohol dependence / (History of) Raynaud’s syndrome /Hypersensitivity to sulpiride, methylphenidate, entacapone, or sulpiride / One first degree or two or more second degree family members with a history of sudden death or ventricular arrhythmia / Suicidality / History of prescribed medication within the last month prior to the start of the study. / History of ‘over the counter’ medication within the last two months (with exception of occasional use of paracetamol, acetylsalicylic acid, and ibuprofen). / Use of MAO inhibitor, anaesthetic, anti\-depressant or anti psychotic drugs within the week prior to the start of the study. / Average use of psychotropic medication or recreational drugs weekly or more. / Cannabis use within 2 weeks prior to the start of the study, and periods of more than 3 months using weekly or more in the last 6 months /Use of psychotropic medication, or of recreational drugs over a period of 72 hours prior to the test sessions, and use of alcohol within the last 24 hours before each measurement. / Average use of more than 3 alcohol beverages daily. / Average use of psychotropic medication or recreational drugs weekly or more. / Habitual smoking, i.e., more than a pack of cigarettes per week a self\-reported inability or unease to cease smoking for 24 hours to testing. / Regular use of corticosteroids. / Uncontrolled hypertension, defined as diastolic blood pressure at rest \> 95 mmHg or systolic blood pressure at rest \> 180 mmHg / Hypotension, defined as diastolic blood pressure \< 50 mm Hg or systolic \< 95 mm Hg or resting pulse rate \< 45 beats/min / Diabetes / Abnormal hearing or (uncorrected) vision. / First degree family member with schizophrenia, bipolar disorder or major depressive disorder