A Commitment Device for Medication Adherence Among HIV Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acquired Immunodeficiency Syndrome
- Sponsor
- National Bureau of Economic Research, Inc.
- Enrollment
- 110
- Locations
- 1
- Primary Endpoint
- Virologic Suppression (pVL =< 200 copies/mL) at Fifth Study Visit
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
We used a randomized trial design combined with a comparison to a non-randomized control group to study patients on appropriate antiretroviral therapy (ART) having virologic failure within a publicly-funded HIV clinic serving Atlanta, GA.
Detailed Description
This study demonstrated the feasibility of using commitment contracts in HIV care. Many previous interventions have produced statistically significant effects on ART adherence that do not persist after the intervention ends. A notable feature of our study is that after the incentives for ART adherence and provider visits were removed, participants who had been offered a commitment contract for ART adherence were more likely to achieve virologic suppression relative to individuals who had been assigned a conditional cash transfer for provider visits and relative to individuals who had been assigned the standard of care, although the difference was only statistically significant in the latter comparison. There were differences in the prevalence of missing outcomes across groups, but these differences were not statistically significant for the unanticipated post-incentive visit and therefore were unlikely to be the explanation for the results. Thus, financial rewards coupled with individual choice can increase engagement in healthy behaviors after incentives are removed.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Attended the Grady Health System Infectious Disease Program (IDP)
- •Most recent HIV-1 plasma RNA viral load (pVL) \> 200 copies/mL; this value must have been measured within the prior 18 months and at least 6 months after starting the current ART regimen
- •English-speaking
Exclusion Criteria
- •Using pillboxes
- •Were planning to relocate
- •Were enrolled in another trial
Outcomes
Primary Outcomes
Virologic Suppression (pVL =< 200 copies/mL) at Fifth Study Visit
Time Frame: 12 months (median)
Secondary Outcomes
- Virologic Suppression (pVL =< 200 copies/mL) at Unanticipated Sixth Study Visit(15 months (median))